Related Experiment Video
Updated: May 29, 2025
Direct Reprogramming of Mouse Fibroblasts into Melanocytes
Published on: August 27, 2021
Stable vitiligo treated by transplantation of autologous melanocytes: a meta-analysis
Xue Cao1, Wentao Zhang2, Zhongyuan Jia3
1Department of Dematology, Bayannur Hospital, No.58 Wulanbuhe Road, Linhe, 015000, Inner Mongolia Autonomous Region, People's Republic of China.
Objective:
To systematically evaluate the efficacy of culture and nonculture autologous melanocyte transplantation and other methods for stable vitiligo.
Methods:
PubMed, Embase, WebofScience, TheCochraneLibrary, Chinese Journal Full-text Database (CNKI), VIP Chinese Scientific Journal Full-text Database (VIP), Wanfang database, were included in the clinical study of autologous cell transplantation for the treatment of stable vitiligo. For the meta-analysis of the corresponding studies with Revman5.3 software.
Results:
17 high-quality studies were included in this meta-analysis, totaling 1199 patients, Meta-analysis showed that there was no significant difference in the efficacy of autologous cultured melanocytes transplantation (CMT) and melanocytes + keratinocytes, CMT and autologous nonculture suspension transplantation (NCES) in stable vitiligo (P > 0.05); There was a significant difference between CMT and CMT + phototherapy in stable vitiligo (P < 0.00001); There was no significant difference in the efficacy of NCES and NCES + other components, NCES and NCES + other therapies, and NCES and NCES + phototherapy for stable vitiligo (P > 0.05); There was a significant difference in the efficacy of cell transplantation and cell transplantation and cell transplantation + other therapy, cell transplantation and cell transplantation + phototherapy,cell transplantation and cell transplantation + narrow spectrum ultraviolet (NBUVB) in stable vitiligo (P < 0.00001).
Conclusion:
Both NCES and CMT transplantation treated stable vitiligo and had no direct relationship with the components contained in the suspension. Melanocyte transplantation and melanocyte transplantation combined with other treatment methods is better than single melanocyte transplantation for vitiligo. Due to the number and quality of included studies, the above conclusions need to be confirmed by more reasonably designed randomized controlled clinical studies.
