Cytotoxicity Profile of Schiff Base Organotin(IV) Complexes: Experimental and Theoretical Approach

Area of Science:

• Organometallic Chemistry
• Medicinal Chemistry
• Computational Chemistry

Background:

• Schiff bases and organotin(IV) complexes are explored for biological applications.
• Understanding structure-activity relationships is crucial for developing new therapeutic agents.

Purpose of the Study:

• To synthesize and characterize a novel Schiff base (L) and its diorganotin(IV) complexes.
• To investigate the biological activity, DNA binding, and molecular interactions of these compounds.
• To evaluate their potential as anticancer agents.

Main Methods:

• Synthesis and characterization using FTIR, multinuclear NMR spectroscopy.
• Theoretical calculations with Gaussian 09 software.
• Molecular docking studies using Autodock.
• DNA binding assays (UV titrations) and in-silico analysis.
• In vitro cytotoxicity evaluation via MTT assay against C6 and SH-SY5Y cell lines.

Main Results:

• Successful synthesis and characterization of Schiff base (L) and its diphenyltin(IV) (1) and dimethyltin(IV) (2) complexes.
• Experimental and theoretical data confirmed the structures.
• Both complexes exhibited intercalative DNA binding.
• Diphenyltin(IV) complex (1) showed significant cytotoxicity against C6 Glioblastoma and SH-SY5Y Neuroblastoma cells.

Conclusions:

• The synthesized diphenyltin(IV) complex (1) exhibits promising anticancer properties.
• The study highlights the potential of organotin(IV) Schiff base complexes in cancer therapy.
• Further research is warranted to explore their therapeutic applications.