Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

MicroRNA profiling in serum and correlation with tumor tissue and clinicopathological parameters in periampullary carcinoma.

Annals of hepato-biliary-pancreatic surgery·2026
Same author

Correction: Pharmacological safety of dimethoxy curcumin-human serum albumin conjugate for potential therapeutic purpose.

Canadian journal of physiology and pharmacology·2026
Same author

Impact of design optimization on cyclic loading performance of novel pedicle screw and comparison with control device: a bilayer model simulation study.

Medical engineering & physics·2026
Same author

Impact of OGG1 and PARP1 Variants on Lead and Cadmium Induced DNA Damage in Metal Handicraft Workers of Jodhpur.

Biological trace element research·2025
Same author

Chondroprotective effects of madecassoside incorporated alginate di-aldehyde gelatin hydrogel on IL-1 β induced in vitro osteoarthritic model.

International journal of biological macromolecules·2025
Same author

Design and characterization of ferulic acid-releasing alginate dialdehyde-gelatin hydrogel for islet cell encapsulation.

International journal of biological macromolecules·2025

Related Experiment Video

Updated: May 29, 2025

Matrix-assisted Autologous Chondrocyte Transplantation for Remodeling and Repair of Chondral Defects in a Rabbit Model
08:58

Matrix-assisted Autologous Chondrocyte Transplantation for Remodeling and Repair of Chondral Defects in a Rabbit Model

Published on: May 21, 2013

14.3K

Platelet-Rich Plasma Loaded Alginate-Based Injectable Hydrogel for Meniscal Tear Repair: In Vivo Evaluation in Lapine

Rajalekshmi Resmi1, Jayasree Parvathy2, Sudha Anjali3

  • 1Division of Polymeric Medical Devices, Biomedical Technology Wing, Sree Chitra Tirunal Institute for Medical Sciences and Technology, Thiruvananthapuram, Kerala, India.

Journal of Biomedical Materials Research. Part B, Applied Biomaterials
|February 1, 2025
PubMed
Summary

Platelet-rich plasma (PRP) in alginate hydrogels enhances fibrocartilage regeneration for meniscal repair. This injectable scaffold promotes tissue healing and reduces inflammation, showing promising results for orthopedic applications.

Keywords:
alginatecytocompatibilityhydrogelmeniscal regenerationplatelet‐rich plasma

More Related Videos

Effects of Allogeneic Platelet-Rich Plasma PRP on the Healing Process of Sectioned Achilles Tendons of Rats: A Methodological Description
07:51

Effects of Allogeneic Platelet-Rich Plasma PRP on the Healing Process of Sectioned Achilles Tendons of Rats: A Methodological Description

Published on: March 19, 2018

9.2K
Athymic Rat Model for Evaluation of Engineered Anterior Cruciate Ligament Grafts
10:32

Athymic Rat Model for Evaluation of Engineered Anterior Cruciate Ligament Grafts

Published on: March 26, 2015

10.3K

Related Experiment Videos

Last Updated: May 29, 2025

Matrix-assisted Autologous Chondrocyte Transplantation for Remodeling and Repair of Chondral Defects in a Rabbit Model
08:58

Matrix-assisted Autologous Chondrocyte Transplantation for Remodeling and Repair of Chondral Defects in a Rabbit Model

Published on: May 21, 2013

14.3K
Effects of Allogeneic Platelet-Rich Plasma PRP on the Healing Process of Sectioned Achilles Tendons of Rats: A Methodological Description
07:51

Effects of Allogeneic Platelet-Rich Plasma PRP on the Healing Process of Sectioned Achilles Tendons of Rats: A Methodological Description

Published on: March 19, 2018

9.2K
Athymic Rat Model for Evaluation of Engineered Anterior Cruciate Ligament Grafts
10:32

Athymic Rat Model for Evaluation of Engineered Anterior Cruciate Ligament Grafts

Published on: March 26, 2015

10.3K

Area of Science:

  • Biomaterials Science
  • Orthopedic Regenerative Medicine
  • Tissue Engineering

Background:

  • Platelet-rich plasma (PRP) contains growth factors beneficial for tissue repair.
  • Alginate hydrogels are injectable scaffolds for cell delivery and tissue regeneration.
  • Meniscal tears often require effective regenerative strategies.

Purpose of the Study:

  • To evaluate the efficacy of injectable alginate hydrogels incorporating PRP for meniscal tissue repair.
  • To assess the in vitro and in vivo performance of PRP-loaded hydrogels in promoting fibrocartilage regeneration.

Main Methods:

  • PRP was incorporated into injectable alginate hydrogels.
  • In vitro studies assessed cell adhesion, proliferation, and extracellular matrix production (DNA, sGAG, collagen type 1).
  • In vivo studies involved surgical induction of meniscal tears in rabbits, treated with hydrogel, PRP-hydrogel, or sham control, followed by 3-month histological and biochemical analysis.

Main Results:

  • In vitro: PRP enhanced fibrochondrocyte adhesion, proliferation, and matrix production on the hydrogel.
  • In vivo: Hydrogel alone facilitated complete meniscal healing, acting as a scaffold.
  • PRP-hydrogel resulted in complete healing with characteristics close to native tissue and reduced inflammation.

Conclusions:

  • Injectable alginate hydrogels are effective scaffolds for meniscal tissue regeneration.
  • Incorporation of PRP further improves healing outcomes, leading to regenerated tissue similar to native meniscal tissue.
  • This PRP-loaded alginate hydrogel system shows significant potential for clinical applications in meniscal repair.