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Updated: Jul 3, 2026

Fabrication and Characterization of Optical Tissue Phantoms Containing Macrostructure
Published on: February 12, 2018
Gravimetric drop-on-demand inkjet deposition for imaging phantoms with traceable activity
Sean P Jollota1, Denis E Bergeron2, R Michael Verkouteren2
1Department of Medical Physics, School of Medicine and Public Health, University of Wisconsin-Madison, Madison, WI, 53705, USA; National Institute of Standards and Technology, Gaithersburg, MD, 20899, USA.
None:
Autoradiography is an important tool in preclinical investigations with alpha-emitting radionuclides. Precise biodistribution studies establish the effectiveness of biological "targeting" strategies, assuring that the promise of targeted alpha therapy (TAT) is realized. There is a need for calibration and test objects (phantoms) to evaluate and support precise autoradiography. Leveraging recent advances in drop-on-demand inkjet methods, we demonstrate the preparation of an autoradiography phantom with activity traceable to primary measurements. With digital autoradiography we demonstrate spatial resolution less than 20 μm. Corrections required to calibrate a digital autoradiography system for activity are discussed.
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