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Potential metabolic sequelae to the terrorist attack of October 7th, 2023

Lawrence Maayan1, Eyal Kalanthroff2, Ezra Cohen3

  • 1New York State Psychiatric Institute, 1051 Riverside Drive, New York, NY, USA.

Journal of Psychiatric Research
|February 1, 2025
PubMed
Abstract

Insights

Exposure to terror events like October 7th, 2023, increases cardiometabolic risk, especially with PTSD. Early screening for psychological and metabolic issues is crucial for affected populations.

Area of Science:

  • Trauma and stress-related disorders
  • Cardiovascular and metabolic health
  • Psychoneuroimmunology

Background:

  • Mass terrorist attacks pose significant psychological and physiological health risks.
  • Understanding long-term health consequences, including cardiometabolic risk, is critical.

Purpose of the Study:

  • To evaluate cardiometabolic risk as a potential sequel to mass terrorist attacks, focusing on the October 7th, 2023 events.
  • To review the literature on PTSD, cardiometabolic illness, and their interconnections.

Main Methods:

  • A narrative review of scientific literature from PubMed, PsycNet, and relevant organizational websites.
  • Focused on PTSD, cardiometabolic illness, underlying mechanisms, and treatment effectiveness.

Main Results:

  • Trauma, especially in childhood, heightens cardiometabolic risk, amplified by PTSD diagnosis in adults.
  • Inflammatory genes (e.g., FKBP5, AHRR, NR3C1) influence PTSD vulnerability and cardiometabolic outcomes.
  • PTSD treatments show some efficacy in reducing cardiometabolic risk in civilians.

Conclusions:

  • Individuals exposed to the October 7th, 2023 terror events require screening for psychological and metabolic sequelae.
  • Primary care settings should integrate this screening into observational research to understand trauma-metabolic relationships and treatment.

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