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Updated: Jun 21, 2026

Culturing Microglia from the Neonatal and Adult Central Nervous System
Published on: August 9, 2013
A mathematical model of microglia glucose metabolism and lactylation with positive feedback
Kamila Larripa1, Anca Rǎdulescu2
1Department of Mathematics, Cal Poly Humboldt, 1 Harpst Street, Arcata, 95521, California, United States.
Abstract:
In this paper, we present and analyze a model for metabolism and lactylation in a single microglia. The model includes positive feedback from lactylation in the glycolytic pathway, and links metabolism and inflammation. Specific pathways include the transition of glucose to pyruvate to lactate in a microglia, as well as the gradient transport of glucose and lactate into and out of the cell. Additionally, the upregulation of certain pathways by either epigenetic modification or the inflammatory response are included. Bifurcation and sensitivity analyses demonstrate the importance of key parameters and pathways in the model, specifically the role of lactylation. Our model is validated by qualitatively reproducing recent in vitro experiments in which exogenous glucose and lactate are modified.
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