Related Experiment Video
Updated: May 29, 2025

Multiplex Therapeutic Drug Monitoring by Isotope-dilution HPLC-MS/MS of Antibiotics in Critical Illnesses
Published on: August 30, 2018
Re-Thinking the Norms of Antibiotic Prescribing in the Neonatal Intensive Care Unit
Genevieve Pg Fung1, Joseph Y Ting2
1Department of Paediatrics, The Chinese University of Hong Kong, 6/F Lui Che Woo Clinical Sciences Building, Prince of Wales Hospital, Shatin, Hong Kong Special Administrative Region, China.
Insights
Antibiotic stewardship programs are crucial in neonatal care to combat antimicrobial resistance. These programs promote judicious antibiotic use, protecting vulnerable newborns from infections and adverse effects.
Area of Science:
- Neonatal Medicine
- Infectious Diseases
- Pharmacology
Background:
- Antibiotics are frequently prescribed for newborns, who are highly susceptible to infections and antibiotic-related complications.
- Inappropriate antibiotic use contributes to the growing problem of antimicrobial resistance.
Purpose of the Study:
- To review studies on the impact of excessive antibiotic exposure in neonates.
- To evaluate the effectiveness of antibiotic stewardship strategies in reducing unnecessary antibiotic use in neonatal intensive care units.
Main Methods:
- Systematic review of existing literature.
- Analysis of data from antibiotic stewardship interventions.
- Examination of antimicrobial resistance patterns.
Main Results:
- Excessive antibiotic use in neonates is linked to increased risks.
- Effective stewardship programs can significantly reduce antibiotic consumption.
- Stewardship interventions help mitigate the development of resistant organisms.
Conclusions:
- Implementing robust antibiotic stewardship programs is essential for optimizing neonatal care.
- Judicious antibiotic use protects vulnerable infants and combats antimicrobial resistance.
- Collaboration between healthcare professionals is key to successful stewardship.
Abstract:
Antibiotics are among the most commonly prescribed medications in neonatal care. Newborns are particularly vulnerable to severe infections and the adverse effects associated with inappropriate antibiotic use. Antibiotic stewardship programs are designed to actively monitor antimicrobial resistance, encourage the judicious use of antibiotics, and collaborate with infection control programs and pharmacy departments to curb the spread of resistant organisms. In this article, the authors will examine studies assessing the impact of excessive antibiotic use and explore the effectiveness of various stewardship strategies aimed at reducing unnecessary antibiotic consumption.
Related Concept Videos
Healthcare Associated Infections II: Preventive Measures
The best practices for preventing healthcare-associated infections include hand hygiene, patient risk...
Standard Precaution
Hand hygiene is the most crucial means to prevent the transmission of disease. Employers are legally required to provide their workers with personal protective equipment (PPE) to minimize exposure or contact with...
Antibiotic Selection
Hand hygiene
Hand washing...
Parentral Nutrition: Centeral and Peripheral Parental Nutrition
PN can be administered through two primary routes:
1. Central Parenteral Nutrition (CPN):
CPN involves delivering a high concentration of nutrients through a large vein. This is typically achieved using a Peripherally Inserted Central Catheter (PICC) or,...
Transmission-based Precautions I: Contact, Enteric, and Droplets
Contact Precautions:
Contact precautions are the measures taken to prevent the transmission of infectious agents, especially epidemiologically important microorganisms such as MRSA or influenza, primarily transmitted through direct or indirect contact with an...

