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Published on: August 3, 2021
Polysaccharide Storage Myopathy
Anna M Firshman1, Stephanie J Valberg2
1Department of Veterinary Population Medicine, University of Minnesota, 225k VMC, 1365 Gortner Avenue, Saint Paul, MN 55108, USA.
Abstract:
Type 1 Polysaccharide Storage Myopathy (PSSM1) is an autosomal dominant glycogen storage disorder affecting more than 20 breeds of horses that can present with a variety of signs, including exertional rhabdomyolysis (ER). It is diagnosed by genetic testing or muscle biopsies containing muscle fibers with abnormal amylase-resistant polysaccharide. Type 2 PSSM has recently been subdivided. PSSM2-ER is a glycogen storage disorder identified in Quarter Horses that causes ER and is diagnosed by muscle biopsy as its genetic basis is unknown. Both PSSM1 and PSSM2-ER respond well to a low nonstructural carbohydrate, high fat diet combined with regular exercise. These forms of PSSM are discussed in this article.
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