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Recent Advances in Integrated Organ-Chip Sensing Toward Robust and User-Friendly Systems
Bryan G Schellberg1, Ryan A Koppes1,2,3, Abigail N Koppes1,2,3
1Department of Chemical Engineering, Northeastern University, Boston, Massachusetts, USA.
Journal of Biomedical Materials Research. Part A
|February 2, 2025
Summary
Organs-on-chips (OOC) offer advanced in vitro models for drug discovery. This review explores integrated sensing technologies for real-time OOC characterization, overcoming limitations of current methods.
Area of Science:
- Biotechnology
- Drug Discovery
- Physiological Modeling
Background:
- Organs-on-chips (OOC) bridge in vitro and in vivo models for drug discovery and disease research.
- OOC systems enhance bio-relevance by integrating physiological stimuli.
- Current methods for OOC microenvironment analysis are limited and labor-intensive, yielding sparse data.
Purpose of the Study:
- To review integrated sensing approaches for OOC systems.
- To address limitations in current OOC characterization methods.
- To enable real-time monitoring of physiological parameters in OOC.
Main Methods:
- Review of current literature on integrated sensing technologies for OOC.
- Analysis of approaches enabling real-time readout of physiological parameters.
- Discussion of methods to engineer improved characterization into OOC devices.
Main Results:
- Integrated sensing offers improved, real-time characterization of OOC.
- These approaches overcome limitations of traditional offline analysis.
- Advancements enable better understanding of cell microenvironment and organ-specific physiology.
Conclusions:
- Integrated sensing is crucial for advancing OOC technology.
- Real-time monitoring enhances OOC utility in drug discovery and pathophysiology.
- Engineering improved characterization methods into OOC is a key future direction.
