Related Experiment Video
Updated: May 29, 2025
Preliminary Study on Acupuncture Combined with Grain-sized Moxibustion for Treating Rheumatoid Arthritis with Finger Joint Pain
Published on: May 16, 2025
ANCA-associated vasculitis in patients with rheumatoid arthritis: A single-center cohort study
Daniel Bolotin1, Courtney O'Brien2, Veena K Ranganath2
1Weill Cornell Medical College, New York, NY, USA.
Aim:
To evaluate characteristics of antineutrophil cytoplasmic antibody (ANCA) associated vasculitis (AAV) in patients with rheumatoid arthritis (RA) and positive ANCA, and, to compare patients with RA+ANCA and RA+AAV.
Methods:
This retrospective study included patients with RA and +ANCA. Patients with AAV were identified and data abstracted. RA+AAV were compared to RA+ANCA to evaluate factors associated with AAV.
Results:
The study included 77 patients with RA+ANCA, mean (±SD) age 62.1 (17.2) years, 79 % female, 65 % seropositive. p-ANCA positivity was noted in 45 % and myeloperoxidase-positivity in 42 %. AAV was diagnosed in 29 %; granulomatosis with polyangiitis (GPA) (45 %), microscopic polyangiitis (36 %), eosinophilic granulomatosis with polyangiitis (5 %), unclassifiable (14 %). Renal (41 %) and upper airway involvement (36 %) were most frequently observed. Diagnosis of RA preceded AAV in 59 %. Positive rheumatoid factor (RhF), myeloperoxidase (MPO)-ANCA, rheumatoid nodules and inflammatory eye disease were more frequent in RA+AAV than RA+ANCA while positive ANCA via immunofluorescence alone and positive dsDNA were more frequent in RA+AAV (p < 0.05). Treatment exposure for RA did not differ between the two groups.
Conclusions:
RA often preceded the diagnosis of AAV and GPA was the most frequently observed AAV. The interplay of +RhF and +MPO antibodies and AAV in patients with RA+ANCA warrants further investigation.
