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Asthma is a chronic respiratory condition for which new therapeutic avenues, including anti-inflammatory drugs like mast cell stabilizers and anti-IgE treatments, continue to be developed.
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Allergic reactions related to drugs are hypersensitivity responses driven by the immune system and bear no connection to the drug's therapeutic action. While drugs in isolation do not trigger an immune response, they can interact with endogenous proteins to form antigens. These antigens stimulate lymphocytes to produce antibodies. IgE-type antibodies attach themselves to mast cells. Upon subsequent exposure to the same stimulus, the antigen-antibody interaction is initiated, unleashing...
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Hypersensitivity, also known as a hypersensitivity reaction or allergic reaction, is a condition where the body's immune system reacts abnormally to a foreign substance. Such substances, that cause hypersensitivity are referred to as an allergen, could be something typically harmless to most people, like pollen or certain foods.
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Measuring Local Anaphylaxis in Mice
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Updates in Food Anaphylaxis Management.

Jay A Lieberman1, Elissa M Abrams2, Priya Katari3

  • 1Department of Pediatrics, Division of Pulmonology, Allergy & Immunology, University of Tennessee Health Science Center, LeBonheur Children's Hospital, Memphis, Tenn.

The Journal of Allergy and Clinical Immunology. in Practice
|February 2, 2025
PubMed
Summary
This summary is machine-generated.

Managing food allergy involves new treatments like oral immunotherapy and therapeutics. Clinicians must stay updated on anaphylaxis management, including epinephrine use, for patients with food allergies.

Keywords:
AnaphylaxisEmergency medical servicesEpinephrineFood allergyTreatment

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Area of Science:

  • Clinical immunology and allergy
  • Emergency medicine

Background:

  • Food allergy management has advanced with new therapeutics and oral immunotherapy.
  • Patients undergoing treatment or avoidance remain at risk for anaphylaxis.
  • Continuous updates in anaphylaxis management are crucial for clinicians.

Purpose of the Study:

  • To review recent advancements in the management of food allergy and anaphylaxis.
  • To provide clinicians with updated information on anaphylaxis diagnosis and treatment.
  • To discuss current recommendations for epinephrine use in food-induced anaphylaxis.

Main Methods:

  • Literature review of recent studies and guidelines on food allergy and anaphylaxis.
  • Analysis of regulatory approvals for new food allergy treatments.
  • Synthesis of current clinical practices in community-based anaphylaxis management.

Main Results:

  • Recent approvals of food allergy therapeutics and widespread use of oral immunotherapy.
  • Updated definitions, diagnostic criteria, and classifications of anaphylaxis.
  • Current recommendations on epinephrine dosing and exploration of novel administration routes.

Conclusions:

  • Despite therapeutic advances, vigilance in anaphylaxis management remains essential.
  • Clinicians require up-to-date knowledge on anaphylaxis protocols and epinephrine administration.
  • This review synthesizes key updates to support optimal patient care in food allergy.