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Potential of SIRT6 modulators in targeting molecular pathways involved in cardiovascular diseases and their
Raushanara Akter1, Fouzia Noor1, Hasan Shahriyer Tonmoy1
1School of Pharmacy, KHA 224 Bir Uttam Rafiqul Islam Avenue, Merul Badda, BRAC University, Dhaka 1212, Bangladesh.
Insights
This review explores how SIRT6 influences cardiovascular diseases (CVDs) by modulating key signaling pathways. It highlights SIRT6 as a potential therapeutic target for treating heart disease and stroke.
Area of Science:
- Biomedical research
- Cardiovascular medicine
- Molecular biology
Background:
- Cardiovascular disease (CVD) is a primary cause of global mortality and morbidity, imposing significant healthcare and economic burdens.
- Major CVDs include ischemic heart disease, stroke, heart failure, atherosclerosis, and hypertension, with ischemic heart disease and stroke causing the most deaths.
- Existing reviews on SIRT6 in CVDs lack a focused analysis of its role in modulating specific signaling pathways for therapeutic targeting.
Purpose of the Study:
- To identify and delineate major signaling pathways implicated in cardiovascular diseases.
- To investigate the potential of SIRT6 in modulating these pathways for CVD improvement and treatment.
- To comprehensively analyze the therapeutic applications of small molecule SIRT6 modulators in cardiovascular disease.
Main Methods:
- Literature review of scientific articles focusing on SIRT6, cardiovascular diseases, and related signaling pathways.
- Analysis of existing research to connect SIRT6 activity with CVD pathogenesis.
- Exploration of potential therapeutic strategies involving SIRT6 modulation.
Main Results:
- SIRT6 plays a critical role in regulating various signaling pathways relevant to cardiovascular health.
- Modulation of SIRT6 activity presents a promising avenue for novel CVD treatments.
- Small molecule modulators targeting SIRT6 show potential for therapeutic intervention in cardiovascular diseases.
Conclusions:
- SIRT6 is a key regulator in cardiovascular disease pathways.
- Targeting SIRT6 offers a promising therapeutic strategy for cardiovascular diseases.
- Small molecule SIRT6 modulators warrant further investigation for clinical application in CVD treatment.
Abstract:
Cardiovascular disease (CVD) is the leading cause of mortality and morbidity, accounting for major public health concerns worldwide. CVD poses an immense burden on the global healthcare system and economy. Ischemic heart disease, stroke, heart failure, atherosclerosis, and hypertension are the major diseases belonging to CVDs and ischemic heart diseases and stroke contribute to most CVD-induced deaths. Previously published review articles focused on the role of SIRT6 in CVDs but did not focus on the important role of SIRT6 in modulating the signaling pathways involved in CVDs and targeting them to treat CVDs. Thus, this review aims to identify and delineate the major signaling pathways that are involved in CVDs and whether SIRT6 can modulate those pathways to improve and treat CVDs. Alongside possible applications of small molecule modulators of SIRT6 in cardiovascular disease treatment have been comprehensively analyzed.
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