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Updated: May 29, 2025
04:41
Measuring Lactase Enzymatic Activity in the Teaching Lab
Published on: August 6, 2018
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Lactylation and human disease
Linlin Wan1, HuiJuan Zhang2, Jialing Liu1
1Department of Pathology, Suzhou Ninth Hospital Affiliated to Soochow University, Jiangsu, China.
Expert Reviews in Molecular Medicine
|February 3, 2025
Summary
Lactylation, an epigenetic modification, links lactate and glycolysis, impacting diseases. Research highlights its role in non-histone proteins, tumor development, and potential therapeutic targets.
Area of Science:
- Biochemistry
- Epigenetics
- Molecular Biology
Background:
- Lactylation, a novel epigenetic modification, is a key mechanism for lactate's physiological functions.
- Lactylation is closely linked to glycolysis, with lactate acting as a mediator in disease processes.
- While histone lactylation is studied, non-histone lactylation offers significant research potential due to its widespread presence in mammalian cells.
Purpose of the Study:
- To summarize the correlations between lactylation and glycolysis, histones, and non-histone proteins.
- To review the relationship between lactylation modifications and tumor development.
- To discuss existing lactylation-related inhibitors for potential therapeutic applications.
Main Methods:
- A systematic literature search was conducted using defined keywords and synonyms.
- Full-text articles were screened based on specific inclusion and exclusion criteria.
Main Results:
- Protein lactylation is implicated in the occurrence and development of various human diseases.
- Lactylation plays crucial roles in tumor cell metabolism, gene transcription, and immune responses.
Conclusions:
- Lactylation is interconnected with glycolysis, histone and non-histone proteins, and tumor progression.
- Understanding lactylation offers new avenues for basic research and clinical tools for lactylation-related diseases.
- Lactylation-related inhibitors are emerging as potential therapeutic strategies.
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