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Diabetic Ketoacidosis in Klinefelter Syndrome Sans Malignancy with Unusually Elevated Levels of CEA: A Case Report
Xinxin Wo1, Xiaoyan Yu1, Lingling Miao1
1Department of Endocrinology, The First Affiliated Hospital of Ningbo University, Ningbo University, Ningbo, People's Republic of China.
Purpose:
Klinefelter's syndrome (KS) is the most common sex chromosome disorder in the male population and is characterized by the presence of one or more X chromosomes. Studies have reported that the proportion of KS patients with diabetes is not low. It is also not uncommon for diabetes patients with poorly controlled blood glucose to have a transient mild increase in their carcinoembryonic antigen (CEA) levels. This study reports the case of Diabetic ketoacidosis (DKA) concurrently with a significant increase in CEA levels (reaching 40.8 ng/mL) in patients with KS.
Methods:
This middle-aged KS patient was immediately treated for DKA upon admission. A series of exams were performed to exclude the possibility of malignant tumors, and the patient's glucose and CEA levels were closely monitored.
Results:
After excluding the possibility of malignant tumors, the patient's CEA level gradually decreased to normal after good glycemic control.
Conclusion:
This is the first report describing significant increases in CEA levels in KS patients with diabetes, which is of great clinical significance for the treatment of diabetes patients.
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