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Assessing donor kidney function: the role of CIRBP in predicting delayed graft function post-transplant
Qianghua Leng1, Maolin Ma1, Zuofu Tang1
1Organ Transplantation Research Institution, Division of Kidney Transplantation, Department of Surgery, The Third Affiliated Hospital of Sun Yat-sen University, Guangzhou, Guangdong, China.
Frontiers in Immunology
|February 3, 2025
Summary
Donor plasma cold-inducible RNA-binding protein (CIRBP) levels can predict delayed graft function (DGF) after kidney transplantation. Higher CIRBP levels indicate increased DGF risk and shorter kidney survival, suggesting CIRBP as a novel biomarker.
Area of Science:
- Nephrology
- Transplant Immunology
- Biomarker Discovery
Background:
- Delayed graft function (DGF) is a significant complication following kidney transplantation, leading to reduced graft survival and increased rejection risk.
- Current methods for predicting DGF are insufficient, necessitating the development of more precise assessment tools.
- Cold-inducible RNA-binding protein (CIRBP) is implicated in acute kidney injury, positioning it as a potential biomarker for transplanted kidney health.
Purpose of the Study:
- To investigate the association between donor plasma cold-inducible RNA-binding protein (CIRBP) levels and the occurrence of delayed graft function (DGF) in kidney transplant recipients.
- To evaluate CIRBP as a predictive biomarker for transplanted kidney function and outcomes.
Main Methods:
- A cohort study included deceased donors and kidney transplant recipients from 2016-2019, categorized into DGF and immediate graft function (IGF) groups.
- Donor plasma CIRBP concentrations were quantified using an enzyme-linked immunosorbent assay (ELISA).
- Statistical analyses, including univariate and multivariate models, were employed to assess the relationship between CIRBP levels and DGF, graft function, and survival.
Main Results:
- Donor plasma CIRBP levels were approximately twice as high in the DGF group compared to the IGF group (6.82 vs. 3.44 ng/mL, P<0.001).
- CIRBP concentrations exceeding 7.92 ng/mL were associated with DGF in all cases.
- Donor plasma CIRBP was confirmed as an independent risk factor for DGF (OR=1.660, P<0.001) and correlated with increased plasma creatinine at 6 months.
Conclusions:
- Donor plasma CIRBP levels serve as an effective predictor for the occurrence of DGF post-kidney transplantation.
- CIRBP emerges as a promising novel biomarker for assessing the function and suitability of transplanted kidneys.
- Elevated CIRBP levels are linked to poorer short-term and long-term kidney graft outcomes.
