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Plant protein-derived anti-breast cancer peptides: sources, therapeutic approaches, mechanisms, and nanoparticle
Deju Zhang1,2,3, Ying Yuan1,2, Qingdong Zeng1,4
1Biobank, Shenzhen Second People's Hospital, First Affiliated Hospital of Shenzhen University, Shenzhen, China.
Abstract:
Breast cancer causes the deaths of approximately 685,000 women annually, posing a severe threat to women's health. Consequently, there is an urgent need for low-cost, low-toxicity and effective therapeutic methods to prevent or mitigate breast cancer progression. PDBP are natural, non-toxic, and affordable substances and have demonstrated excellent anti-breast cancer activities in inhibiting proliferation, migration, and invasion, and promoting apoptosis both in vitro and in vivo, thus effectively preventing or inhibiting breast cancer. However, there are no comprehensive reviews summarizing the effects and mechanisms of PDBP on the treatment of breast cancer. Therefore, this review described the inhibitory effects and mechanisms of active peptides from different plant protein sources on breast cancer. Additionally, we summarized the advantages and preparation methods of plant protein-derived anticancer peptide-encapsulated nanoparticles and their effects in inhibiting breast cancer. This review provides a scientific basis for understanding the anti-breast cancer mechanisms of PDBP and offers guidance for the development of therapeutic adjuvants enriched with these peptides.
Insights
Plant protein-derived anticancer peptides (PDBP) show promise in inhibiting breast cancer growth and spread. This review details their mechanisms and potential as affordable, low-toxicity therapeutic adjuvants.
Area of Science:
- Oncology
- Biochemistry
- Pharmacology
Background:
- Breast cancer is a leading cause of death in women, necessitating novel therapeutic strategies.
- Plant protein-derived anticancer peptides (PDBP) offer a low-cost, low-toxicity alternative for cancer treatment.
- Existing research highlights PDBP's efficacy in inhibiting cancer cell proliferation, migration, invasion, and promoting apoptosis.
Purpose of the Study:
- To comprehensively review the inhibitory effects and underlying mechanisms of PDBP against breast cancer.
- To summarize the advantages and preparation of PDBP-encapsulated nanoparticles for cancer therapy.
- To provide a scientific foundation for developing PDBP-based therapeutic adjuvants.
Main Methods:
- Literature review of studies on plant protein-derived peptides and their anti-breast cancer activities.
- Analysis of in vitro and in vivo experimental data on PDBP efficacy.
- Examination of nanoparticle encapsulation techniques for PDBP delivery.
Main Results:
- PDBP demonstrate significant anti-breast cancer properties, inhibiting key cancer progression pathways.
- Nanoparticle encapsulation enhances the stability and efficacy of PDBP.
- Various plant sources yield peptides with distinct anti-cancer mechanisms.
Conclusions:
- PDBP represent a promising class of natural compounds for breast cancer prevention and treatment.
- Further research into PDBP mechanisms and delivery systems can lead to effective therapeutic adjuvants.
- This review consolidates current knowledge, guiding future development in plant-derived cancer therapeutics.
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