Synthetic Approaches to the New Drugs Approved during 2023

Area of Science:

• Medicinal Chemistry
• Organic Synthesis
• Drug Discovery

Background:

• Annual review series focusing on novel drug approvals.
• Synthetic chemistry is crucial for drug development and patient treatment.
• 2023 saw the approval of 28 new small molecule drugs worldwide.

Purpose of the Study:

• To review the synthetic routes for 28 small molecule drugs approved in 2023.
• To provide insights into the discovery, development, and synthetic strategies of these new drugs.
• To highlight the role of synthetic chemistry in delivering novel therapeutics.

Main Methods:

• Literature review of primary and patent sources.
• Analysis of synthetic approaches for 2023 approved drugs.
• Summarization of drug mechanisms of action and developmental history.

Main Results:

• Detailed synthetic pathways for 28 small molecule drugs approved in 2023 are presented.
• Information on each drug's mechanism of action and discovery history is included.
• Likely synthetic routes used for clinical studies and development are identified.

Conclusions:

• Synthetic chemistry plays a pivotal role in the successful development and delivery of new drugs.
• The review offers a comprehensive overview of the synthetic strategies employed for recent pharmaceutical advancements.
• Understanding these synthetic routes aids in future drug development and manufacturing processes.