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Updated: May 29, 2025
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Subcutaneous Administration of Muscarinic Antagonists and Triple-Immunostaining of the Levator Auris Longus Muscle in Mice
Published on: September 8, 2011
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11038 Neostigmine ̶̶ The underutilized drug worth remembering
Carolina Broco Fernández1, Ana Belén Domínguez Carbajo1, Santiago Vivas Alegre2
1Digestive Diseases, Complejo Asistencial Universitario de León, España.
Revista Espanola De Enfermedades Digestivas
|February 3, 2025
Summary
Neostigmine effectively treats Ogilvie syndrome, a rare intestinal motility disorder, with a 70% success rate. This study suggests neostigmine is a safe and effective alternative to invasive treatments for this condition.
Area of Science:
- Gastroenterology
- Pharmacology
Background:
- Ogilvie syndrome is a rare intestinal motility disorder.
- It is associated with parasympathetic plexus dysfunction.
- Complications include ischemia and perforation, particularly in comorbid patients.
Purpose of the Study:
- To assess the efficacy and safety of neostigmine in treating Ogilvie syndrome.
- To evaluate neostigmine as a potential first-line therapy.
Main Methods:
- Retrospective observational study.
- 13 patients with Ogilvie syndrome treated with neostigmine after failure of initial therapies.
- Data collected from January 2021 to December 2023.
Main Results:
- Symptom resolution in 70% of patients.
- A single dose of neostigmine was successful in 54% of cases.
- No severe adverse reactions were reported.
Conclusions:
- Neostigmine demonstrates high efficacy and safety for Ogilvie syndrome.
- It offers a viable therapeutic alternative to invasive interventions.
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