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Updated: May 29, 2025
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Measuring Frailty in HIV-infected Individuals. Identification of Frail Patients is the First Step to Amelioration and Reversal of Frailty
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Association Between Frailty and Mortality, Falls and Hospitalisation Among Patients Undergoing Dialysis: A Systematic
Wan-Qiao He1,2, Xiao-Ming Zhang3, Yi-Zhen Zhang2,4
1Chengdu Integrated TCM & Western Medicine Hospital, Chengdu, Sichuan, China.
Nursing Open
|February 3, 2025
Summary
Frailty significantly predicts adverse outcomes like mortality, falls, and hospitalization in dialysis patients. Early screening and interventions for frailty are crucial for this vulnerable population.
Area of Science:
- Gerontology
- Nephrology
- Clinical Epidemiology
Background:
- Frailty is a recognized risk factor for adverse events in older adults.
- Its impact on patients undergoing dialysis requires further robust verification.
Purpose of the Study:
- To systematically review and meta-analyze the association between frailty and adverse outcomes (mortality, falls, hospitalization) in dialysis patients.
Main Methods:
- A comprehensive systematic review and meta-analysis of cohort studies was conducted.
- Searches across multiple databases (PubMed, EMbase, Cochrane, etc.) up to April 2022 identified relevant studies.
- Risk of bias was assessed using the Newcastle Ottawa Scale, and a random effects model was employed for analysis.
Main Results:
- The analysis included 26 observational cohort studies with 14,089 dialysis patients.
- Frailty was confirmed as a significant predictor of adverse outcomes, including mortality, falls, and hospitalizations.
- Pooled results demonstrated a strong association between frailty and negative health events in this cohort.
Conclusions:
- Frailty is a powerful predictor of adverse outcomes in patients undergoing dialysis.
- Routine screening for frailty in dialysis patients is recommended.
- Implementing early interventions for frailty may improve patient outcomes and reduce adverse events.
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