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Related Experiment Videos

In vitro studies on human primary obstructed megaureters.

L Hertle, H Nawrath

    The Journal of Urology
    |May 1, 1985
    PubMed
    Summary

    Muscle strips from pediatric primary obstructed megaureters showed spontaneous activity, unlike adult megaureters or normal ureters. Norepinephrine induced tonic contractions in all megaureters, suggesting abnormal calcium handling in this condition.

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    Area of Science:

    • Urology
    • Physiology
    • Pediatric Surgery

    Background:

    • Primary obstructed megaureters are a congenital condition affecting the ureter.
    • Understanding the mechanical properties of megaureter tissue is crucial for diagnosing and managing this condition.

    Purpose of the Study:

    • To investigate the mechanical activity of isolated muscle strips from primary obstructed megaureters.
    • To compare the contractile responses of megaureter tissue with normal ureteral tissue.

    Main Methods:

    • Isolated muscle strips from dilated segments of primary obstructed megaureters (2 children, 2 adults) were studied.
    • Mechanical activity was compared to normal ureteral segments from tumor nephrectomies.
    • Responses to norepinephrine (an alpha-adrenoceptor stimulant) were analyzed.

    Main Results:

    • Pediatric megaureter muscle strips exhibited stable spontaneous phasic activity, unlike adult megaureter or normal ureter tissues.
    • Norepinephrine induced a marked tonic contraction in all megaureter preparations, a response not seen in normal ureters.
    • Normal ureters showed increased frequency of spontaneous contractions upon norepinephrine stimulation.

    Conclusions:

    • Primary obstructed megaureters, particularly in children, display distinct mechanical properties compared to normal ureters.
    • Abnormal alpha-adrenoceptor response in megaureters may stem from altered subcellular calcium distribution.
    • In vitro findings correlate with radiographic evidence of impaired ureteral peristalsis in primary obstructed megaureters.

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