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Updated: May 29, 2025

Facile Preparation of 2Z,4E-Dienamides by the Olefination of Electron-deficient Alkenes with Allyl Acetate
Published on: June 21, 2017
Stereoselective Synthesis of Conjugated Dienes via Aryl-to-Vinyl 1,4-Nickel Migration and Reductive Cross-Coupling
Guo-An Ren1, Hong-Zhe Li1, Yi-Ming Duan1
1State Key Laboratory of Applied Organic Chemistry, School of Chemistry and Chemical Engineering, Lanzhou University, Lanzhou 730000, P.R. China.
Abstract:
Selective functionalization of remote C-H bonds via metal/hydride shift and cross-coupling represents a powerful strategy in modern synthetic chemistry. Herein, we report a highly efficient aryl-to-vinyl 1,4-nickel migration coupled with a reductive cross-coupling for the stereoselective synthesis of conjugated dienes. This tandem process proceeds under mild conditions, accommodates a wide range of substrates, and achieves excellent regioselectivity and Z/E stereoselectivity, offering a valuable method for constructing multisubstituted conjugated dienes.
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