Nickel-Catalyzed Cross-Coupling of Oxime Esters with Arylboronic Acids
Yong-Chao Zhou1, Zhuo-Min Chi1, Jia-Hui Zhao1
1State Key Laboratory of Applied Organic Chemistry and College of Chemistry and Chemical Engineering, Lanzhou University, Lanzhou 730000, P. R. China.
Abstract:
We report a nickel-catalyzed cross-coupling reaction between oxime ester radical precursors and arylboronic acids that via a nitrogen-centered radical mechanism generates radicals from oxime esters. Using acyl, cyclobutanone, and benzyl oxime esters, this method successfully achieves the acylation, cyanoalkylation, and benzylation of arylboronic acids, demonstrating a broad scope. Notably, this strategy is applicable to the synthesis of the drug molecule fenofibrate and the bioactive molecule naphthylphenstatin, highlighting its potential utility for constructing complex bioactive molecules.
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