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Cerebrovascular accidents association between serum trace elements and toxic metals level, a case-control study
Khosro Jamebozorgi1, Alireza Kooshki2, Mahbobeh Saljoughi2
1Faculty of Medicine, Zabol University of Medical Sciences, Zabol, Iran.
Plos One
|February 3, 2025
Summary
Elevated serum copper and lead levels, along with lower nickel, are linked to increased cerebrovascular accident (CVA) risk. Further research is needed to understand these metal-CVA associations.
Area of Science:
- Neurology
- Environmental Health
- Toxicology
Background:
- Cerebrovascular accidents (CVAs) are a leading cause of morbidity.
- Identifying risk factors for ischemic CVAs is critical for prevention.
- Metal concentration is a potential risk factor for neurological complications.
Purpose of the Study:
- To investigate the association between serum metal levels and the occurrence of cerebrovascular accidents (CVAs).
Main Methods:
- A case-control study involving 70 CVA patients and 70 controls.
- Serum levels of Iron, Cobalt, Nickel, Copper, Zinc, Manganese, Lead, and Mercury were measured using ICP-MS.
- Logistic regression analysis was used to assess the association between metal levels and CVA.
Main Results:
- Serum Copper and Lead levels were significantly higher in the CVA group (P < 0.001, P = 0.002).
- Serum Nickel levels were significantly lower in the CVA group (P = 0.003).
- Logistic regression showed Copper, Lead, and Zinc were associated with increased CVA risk (ORs: 1.34, 1.19, 1.01).
Conclusions:
- Specific serum metal concentrations are associated with an increased risk of cerebrovascular accidents.
- Understanding these metal-CVA links is crucial for clinical practice and public health.
- Further research with larger populations is required to elucidate the exact pathogenesis.
