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Related Experiment Video

Updated: May 29, 2025

Techniques to Induce and Quantify Cellular Senescence

Techniques to Induce and Quantify Cellular Senescence

Published on: May 1, 2017

Cellular senescence and PAPP-A.

Cheryl A Conover¹

¹Department of Endocrinology, Endocrine Research Unit, Mayo Clinic, 200 First Street SW, Rochester, MN 55905, United States of America.

Growth Hormone & IGF Research : Official Journal of the Growth Hormone Research Society and the International IGF Research Society

|February 4, 2025

Summary

This summary is machine-generated.

Cellular senescence, a state of irreversible growth arrest, and its secreted factors influence mammalian aging. A protease called PAPP-A regulates insulin-like growth factor (IGF)-I bioavailability, impacting growth and aging processes.

Keywords:

Cellular senescence Insulin-like growth factor PAPP-A SASP

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Area of Science:

Gerontology
Cell Biology
Biochemistry

Background:

Cellular senescence is a key factor in organismal aging and age-related diseases.
The senescence-associated secretome contributes to tissue microenvironment alterations.
Pregnancy-associated plasma protein-A (PAPP-A) is a metalloproteinase implicated in growth regulation.

Purpose of the Study:

To review the role of cellular senescence in aging.
To explore the function of PAPP-A in regulating growth factor bioavailability.
To present a novel perspective on the interplay between cellular senescence and PAPP-A.

Main Methods:

Literature review of studies on cellular senescence.
Analysis of research on PAPP-A function and regulation.
Synthesis of current understanding of senescence and PAPP-A in aging.

Main Results:

Cellular senescence significantly impacts mammalian growth and aging.
PAPP-A modulates the bioavailability of insulin-like growth factor (IGF)-I.
PAPP-A's role in senescence presents new avenues for aging research.

Conclusions:

Cellular senescence and PAPP-A are critical regulators of growth and aging.
Understanding PAPP-A's function in senescence may offer therapeutic targets for age-related conditions.
Further research into the senescence-PAPP-A axis is warranted.