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Updated: May 29, 2025

Reconstruct Human Retinoblastoma In Vitro
Published on: October 11, 2022
The Role of Small Extracellular Vesicles in Retinoblastoma Development and Progression
Jyothi Attem1, Geeta K Vemuganti1
1School of Medical Sciences, Science Complex, University of Hyderabad, Hyderabad, India.
None:
A growing body of research on extracellular vesicles (EVs) in cancer has revealed their novel and crucial activities in the progression of tumors while also paving the way for potential therapeutic interventions. It is now known that EVs are natural delivery vehicles for particular payloads of source cells, enabling them to influence diverse functions of cells both in healthy and malignant cells. In this review, we comprehensively summarize mechanistic insights into sEV roles in RB, the most frequent intraocular malignancy that affects the retina of young children. We also explore the therapeutic potential of sEVs as an emerging area as biomarkers and vehicles for targeted therapy. Additionally, we address the potential challenges and limitations of translating sEVs-based technologies into clinical practice.
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