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Updated: May 29, 2025

Examining BCL-2 Family Function with Large Unilamellar Vesicles
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Inhibitory Potential and Binding Thermodynamics of Scyllatoxin-Based BH3 Domain Mimetics Targeting Repressor BCL2

H A D B Amarasiri1, Danushka Arachchige1, Matthew J K Vince1,2

  • 1Department of Chemistry and Biochemistry, Ohio University, Athens, Ohio, USA.

Journal of Molecular Recognition : JMR
|February 5, 2025
PubMed
Summary

Researchers developed novel BH3 domain mimetics, ScTx-Bax, to study B-cell lymphoma 2 (BCL2) protein interactions. These mimetics reveal that flexible BH3 domains enhance inhibition of Bcl-2, impacting apoptosis regulation.

Keywords:
BH3 domainbinding thermodynamicscompetitive bindingdisulfide linkageeffector BCL2 proteinspeptide mimeticprotein–protein interactionrepressor BCL2 proteinsscyllatoxin

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