Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Variation01:19

Variation

6.7K
An important characteristic of any set of data is the variation in the data. In some data sets, the data values are concentrated closely near the mean; in other data sets, the data values are more widely spread out from the mean. The most common measure of variation, or spread, is the standard deviation, which is the square root of variance.
When independent and dependent variables are plotted on a scatter plot, the slope of a line is a value that describes the rate of change between the two...
6.7K
Variation: Normal Distribution, Range, and Standard Deviation02:32

Variation: Normal Distribution, Range, and Standard Deviation

22.2K
In the field of psychology, there are several ways to organize measurements of a trait, feature, or characteristic (i.e., variables). Qualitative data, such as ethnicity, can be tabulated into a frequency count to provide information about the proportion, as well as the variety of groups in a sample or population. On the other hand, researchers can perform a wider set of calculations on quantitative data. The mean, mode, and median, for instance, are central tendency measures to identify a...
22.2K
Regression Toward the Mean01:52

Regression Toward the Mean

6.3K
Regression toward the mean (“RTM”) is a phenomenon in which extremely high or low values—for example, and individual’s blood pressure at a particular moment—appear closer to a group’s average upon remeasuring. Although this statistical peculiarity is the result of random error and chance, it has been problematic across various medical, scientific, financial and psychological applications. In particular, RTM, if not taken into account, can interfere when...
6.3K
Autism Spectrum Disorder01:19

Autism Spectrum Disorder

57
Autism spectrum disorder (ASD) is a neurodevelopmental condition marked by persistent deficits in social communication and interaction alongside restrictive and repetitive behaviors or interests. ASD is sometimes accompanied by intellectual impairment.
These core symptoms manifest differently among individuals, ranging from mild to severe. The disorder's complexity extends beyond its clinical presentation, encompassing a diverse range of biological, cognitive, and sociocultural influences.
57
Oppositional Defiant Disorder01:30

Oppositional Defiant Disorder

23
A persistent pattern of angry or irritable mood, defiant behavior, or vindictiveness characterizes Oppositional Defiant Disorder (ODD). Symptoms must occur over at least six months, involve interactions with individuals beyond siblings, and meet specific diagnostic criteria to be clinically significant. The disorder affects emotional regulation, social interactions, and behavior, often manifesting early in life and influencing long-term development and functioning.
Diagnostic Criteria and...
23

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Risk for Autism Across Generations.

Biological psychiatry·2026
Same author

From QI-disability to QID-12: creating a brief proxy-report measure of quality of life for children with intellectual disability.

Quality of life research : an international journal of quality of life aspects of treatment, care and rehabilitation·2026
Same author

Behavioral Features in Phelan-McDermid Syndrome: Characteristics and Genetic and Metabolic Contributions in a Cohort of 56 Individuals.

Genes·2026
Same author

Addressing the challenges of intellectual disability identification for health policy and research in Australia.

Frontiers in psychiatry·2026
Same author

Functional skills in MECP2 duplication syndrome: developmental dynamics and regression.

Orphanet journal of rare diseases·2026
Same author

Longitudinal Rett syndrome behaviour questionnaire scores and their associations with genotype and trajectories of mobility, weight and seizure frequency status.

Journal of neurodevelopmental disorders·2026
Same journal

Beyond the Wait-and-See: Data-Driven Decision Points for Guiding Selective Serotonin Reuptake Inhibitor Treatment and Cognitive Behavioral Therapy in Pediatric Anxiety Disorders.

Journal of child and adolescent psychopharmacology·2026
Same journal

Efficacy and Safety of Cannabinoid-Based Products in Children and Adolescents with Autism Spectrum Disorder, Fragile X Syndrome and Rett Syndrome: A Systematic Review.

Journal of child and adolescent psychopharmacology·2026
Same journal

Low Emotional Awareness and Altered Frontostriatal Functional Connectivity During Reward Processing Prospectively Predict Depressive Symptoms in At-Risk Youth.

Journal of child and adolescent psychopharmacology·2026
Same journal

Testing a Developmental Cascade Model from Prenatal Maternal Emotion Dysregulation to Toddler Behavior Dysregulation Through Postnatal Parenting Stress and Infant Physiology.

Journal of child and adolescent psychopharmacology·2026
Same journal

Neighborhood Disadvantage as a Moderator of Children's Response to a Dyadic Positive Affect Intervention for Children of Mothers with Depressive Symptoms.

Journal of child and adolescent psychopharmacology·2026
Same journal

<i>Letter:</i> Psychosis Following Hormonal Therapy in NAA15-Related Neurodevelopmental Disorder.

Journal of child and adolescent psychopharmacology·2026
See all related articles

Related Experiment Video

Updated: May 29, 2025

Use of a Video Scoring Anchor for Rapid Serial Assessment of Social Communication in Toddlers
09:16

Use of a Video Scoring Anchor for Rapid Serial Assessment of Social Communication in Toddlers

Published on: March 14, 2018

10.2K

Rett Syndrome Behaviour Questionnaire: Variability of Scores and Related Factors.

Walter E Kaufmann1,2, Lindsay M Oberman3, Jenny Downs4

  • 1Department of Neurology, Boston Children's Hospital, Boston, Massachusetts, USA.

Journal of Child and Adolescent Psychopharmacology
|February 5, 2025
PubMed
Summary
This summary is machine-generated.

Rett syndrome (RTT) research shows the Rett Syndrome Behaviour Questionnaire (RSBQ) has variable scores. Standardizing RSBQ administration and reporting is crucial for its use in clinical trials and understanding RTT severity.

Keywords:
Rett Syndrome Behaviour QuestionnaireRett syndrome (RTT)clinical outcomesneurobehavioral symptomspsychometrics

More Related Videos

Psychophysiological Assessment of the Effectiveness of Emotion Regulation Strategies in Childhood
08:09

Psychophysiological Assessment of the Effectiveness of Emotion Regulation Strategies in Childhood

Published on: February 11, 2017

11.4K
Modeling Verbal Behavior Deficits with the Stimulus Control Ratio Equation, SCoRE
06:57

Modeling Verbal Behavior Deficits with the Stimulus Control Ratio Equation, SCoRE

Published on: May 14, 2019

10.4K

Related Experiment Videos

Last Updated: May 29, 2025

Use of a Video Scoring Anchor for Rapid Serial Assessment of Social Communication in Toddlers
09:16

Use of a Video Scoring Anchor for Rapid Serial Assessment of Social Communication in Toddlers

Published on: March 14, 2018

10.2K
Psychophysiological Assessment of the Effectiveness of Emotion Regulation Strategies in Childhood
08:09

Psychophysiological Assessment of the Effectiveness of Emotion Regulation Strategies in Childhood

Published on: February 11, 2017

11.4K
Modeling Verbal Behavior Deficits with the Stimulus Control Ratio Equation, SCoRE
06:57

Modeling Verbal Behavior Deficits with the Stimulus Control Ratio Equation, SCoRE

Published on: May 14, 2019

10.4K

Area of Science:

  • Neuroscience
  • Genetics
  • Clinical Psychology

Background:

  • Rett syndrome (RTT) is a severe neurodevelopmental disorder primarily affecting females, linked to MECP2 gene variants.
  • The Rett Syndrome Behaviour Questionnaire (RSBQ) is increasingly used in RTT clinical trials and research.
  • Concerns exist regarding the RSBQ's construct validity, content, structure, and psychometric properties for use as a global clinical severity scale.

Purpose of the Study:

  • To analyze existing literature data on Rett Syndrome Behaviour Questionnaire (RSBQ) scores.
  • To investigate the variability of RSBQ scores and identify influencing factors.
  • To inform the appropriate use and interpretation of RSBQ data in RTT research and clinical practice.

Main Methods:

  • Systematic literature search to identify publications reporting RSBQ total and/or subscale scores.
  • Analysis of reported means and standard deviations, calculating variance-to-mean ratios (VMR) to assess score variability.
  • Comparison of VMRs and means across different study types, age groups, and administration methods using Welch t-tests.

Main Results:

  • Wide but comparable ranges of mean total RSBQ scores were observed between observational studies and clinical trials.
  • Observational studies exhibited significantly higher VMRs compared to clinical trials.
  • RSBQ subscale variability differed, with high variability in General Mood and Breathing Problems, and low variability in Hand Behaviours, Body Rocking, and Expressionless Face. Pediatric groups showed greater variability than adults. Interviews and electronic administration yielded less variability than paper forms.

Conclusions:

  • Comprehensive reporting of RSBQ data, cohort characteristics, and methodology is essential.
  • Standardized RSBQ administration methods, like advanced data capture systems, should be deployed.
  • Further psychometric validation of RSBQ subscales is needed for their use as outcome measures, alongside investigations into score stability and influencing factors.