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Updated: May 29, 2025
Tracking the Mammary Architectural Features and Detecting Breast Cancer with Magnetic Resonance Diffusion Tensor Imaging
Published on: December 15, 2014
Deep learning-based breast cancer diagnosis in breast MRI: systematic review and meta-analysis
Kamarul Amin Abdullah1,2, Sara Marziali1,3, Muzna Nanaa1
1Department of Radiology, University of Cambridge School of Clinical Medicine, Cambridge Biomedical Campus, Cambridge, UK.
Objectives:
The aim of this work is to evaluate the performance of deep learning (DL) models for breast cancer diagnosis with MRI.
Materials And Methods:
A literature search was conducted on Web of Science, PubMed, and IEEE Xplore for relevant studies published from January 2015 to February 2024. The study was registered with the PROSPERO International Prospective Register of Systematic Reviews (protocol no. CRD42024485371). The quality assessment of diagnostic accuracy studies-2 (QUADAS2) tool and the Must AI Criteria-10 (MAIC-10) checklist were used to assess quality and risk of bias. The meta-analysis included studies reporting DL for breast cancer diagnosis and their performance, from which pooled summary estimates for the area under the curve (AUC), sensitivity, and specificity were calculated.
Results:
A total of 40 studies were included, of which only 21 were eligible for quantitative analysis. Convolutional neural networks (CNNs) were used in 62.5% (25/40) of the implemented models, with the remaining 37.5% (15/40) hybrid composite models (HCMs). The pooled estimates of AUC, sensitivity, and specificity were 0.90 (95% CI: 0.87, 0.93), 88% (95% CI: 86, 91%), and 90% (95% CI: 87, 93%), respectively.
Conclusions:
DL models used for breast cancer diagnosis on MRI achieve high performance. However, there is considerable inherent variability in this analysis. Therefore, continuous evaluation and refinement of DL models is essential to ensure their practicality in the clinical setting.
Key Points:
Question Can DL models improve diagnostic accuracy in breast MRI, addressing challenges like overfitting and heterogeneity in study designs and imaging sequences? Findings DL achieved high diagnostic accuracy (AUC 0.90, sensitivity 88%, specificity 90%) in breast MRI, with training size significantly impacting performance metrics (p < 0.001). Clinical relevance DL models demonstrate high accuracy in breast cancer diagnosis using MRI, showing the potential to enhance diagnostic confidence and reduce radiologist workload, especially with larger datasets minimizing overfitting and improving clinical reliability.
