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Association between parity and gravidity & hypertension and blood pressure: protocol for a systematic review and
Nabilah Gulamhusein1,2, Badal S B Pattar1,2, Sandra M Dumanski1,2,3,4
1Cumming School of Medicine, University of Calgary, Calgary, Alberta, Canada.
Insights
This systematic review examines the link between childbirth history (parity and gravidity) and hypertension in women. Findings will clarify if pregnancy history impacts blood pressure and cardiovascular disease risk.
Area of Science:
- Reproductive Health
- Cardiovascular Epidemiology
- Clinical Research Methodology
Background:
- Cardiovascular disease is a leading cause of mortality in women globally.
- Hypertension is a significant, modifiable risk factor for cardiovascular disease.
- Previous research on parity, gravidity, and hypertension presents conflicting findings.
Purpose of the Study:
- To systematically review and estimate the association between parity and gravidity and hypertension.
- To analyze the relationship between parity and gravidity and blood pressure levels.
- To provide a comprehensive overview of existing evidence on this topic.
Main Methods:
- A systematic review of observational cohort studies, case-control studies, and randomized controlled trials.
- Comprehensive search of multiple electronic databases (e.g., MEDLINE, Web of Science) up to January 2025.
- Data extraction on study characteristics, comorbidities, parity, gravidity, hypertension incidence, and blood pressure changes, followed by random-effects meta-analysis if data permit.
Main Results:
- (Results will be populated after study completion)
Conclusions:
- (Conclusions will be populated after study completion)
Introduction:
Cardiovascular disease is the leading cause of death among women worldwide, and hypertension is one of the most prevalent and modifiable risk factors. Parity and gravidity, independent of pregnancy complications, have each been associated with hypertension, although results are conflicting. Therefore, we propose to estimate the association between parity and gravidity with hypertension and blood pressure in a systematic review of the literature.
Methods And Analysis:
A systematic review will be conducted to estimate the association between parity and gravidity and hypertension and blood pressure. Electronic databases (Excerpta Medica Database, Ovid MEDLINE, Cochrane Central Register of Controlled Trials, Cumulative Index to Nursing and Allied Health Literature Plus and Web of Science) will be searched from inception to January 2025. Two investigators will independently screen identified abstracts and select observational cohort studies, case-control studies and randomised controlled trials examining parity or gravidity and hypertension or blood pressure. Extracted data will include study and population characteristics, comorbidities, parity, gravidity, incidence of hypertension and changes in blood pressure, study quality and risk of bias. If there are sufficient data, they will be summarised using random effects meta-analysis to estimate the pooled risk ratio or odds ratio of hypertension. Stratified and subgroup analyses will be used to explore potential sources of heterogeneity.
Prospero Registration Number:
CRD42024560535.
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