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Multisystem inflammatory syndrome in children (MIS-C) associated with COVID-19, clinical characteristics: A

Marwan Shalabi1, Salam Ghanem2, Iyad Al-Ammouri3

  • 1Department of Pediatrics, School of Medicine, The Hashemite University, Amman, Jordan.

Global Epidemiology
|February 6, 2025
PubMed

Insights

Multisystem inflammatory syndrome in children (MIS-C) is a COVID-19 complication. This study of 74 Jordanian children found varied severity, with abdominal pain common, but no deaths occurred.

Area of Science:

  • Pediatrics
  • Infectious Diseases
  • Public Health

Background:

  • Multisystem inflammatory syndrome in children (MIS-C) is a serious condition linked to COVID-19.
  • Understanding MIS-C's clinical presentation and outcomes in diverse populations is crucial.

Purpose of the Study:

  • To describe the clinical course, management, and outcomes of MIS-C in Jordanian children.
  • To compare findings with global MIS-C data.

Main Methods:

  • A multicenter retrospective study of 74 children diagnosed with MIS-C in Jordan.
  • Data collected included clinical, laboratory, radiological, and therapeutic information.

Main Results:

  • Common symptoms included fever, abdominal pain, and hypoxia.
  • Cardiac involvement was infrequent and lacked coronary findings.
  • Treatments primarily involved Corticosteroids and IVIG; no mortality was observed, but some cases required Pediatric Intensive Care Unit admission.

Conclusions:

  • The clinical spectrum of MIS-C in Jordan mirrors global observations.
  • Abdominal pain was a prevalent symptom, sometimes leading to misdiagnosis as surgical emergencies.
  • While severe cases occurred, the overall outcome in this cohort was favorable, with no reported deaths.
Abstract

Keywords:
COVID-19Critical careMultisystem inflammatory syndrome temporally associated with COVID-19PediatricSARS-CoV-2ShockToxic shock syndrome

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