Related Experiment Video
Updated: May 29, 2025
06:13
Endoscopic Septoplasty with Limited Two-line Resection: Minimally Invasive Surgery for Septal Deviation
Published on: June 20, 2018
16.6K
Unveiling the Silent Sinus Syndrome: A Familial Case Series Exploring Chronic Maxillary Atelectasis
Giovanny E Perez1, Antonio Bures2, Ana L Melero-Pardo3
1Otolaryngology - Head and Neck Surgery, University of Puerto Rico, Medical Sciences Campus, San Juan, PRI.
Cureus
|February 6, 2025
Summary
Familial chronic maxillary atelectasis (CMA) and silent sinus syndrome (SSS) occurred in three relatives. This suggests a potential genetic link for these rare sinus conditions, often presenting with eye symptoms rather than nasal issues.
Area of Science:
- Otolaryngology and Ophthalmology
- Genetics and Hereditary Diseases
Background:
- Chronic maxillary atelectasis (CMA) involves reduced maxillary sinus volume due to inward bowing of sinus walls.
- Silent sinus syndrome (SSS) is a rare CMA manifestation with structural changes but minimal nasal symptoms, often presenting with enophthalmos.
Observation:
- A case series documented familial occurrence of CMA and SSS in three male family members.
- Clinical presentations varied, including different degrees of nasal symptoms and imaging findings of maxillary sinus opacification and collapse.
Findings:
- The observed familial clustering suggests a potential genetic or hereditary etiology for CMA and SSS.
- This contrasts with the typical understanding of these conditions, highlighting an under-explored aspect in current literature.
Implications:
- Investigating a genetic component could refine diagnostic approaches for CMA and SSS.
- Understanding hereditary factors may lead to earlier identification and management of affected individuals and families.
Related Concept Videos
01:23Chronic Pharyngitis
989
Chronic pharyngitis refers to persistent inflammation of the pharyngial mucosa.
Etiology
It often arises from persistent viral or bacterial infections affecting sinuses and tonsils.
Additional contributing factors include inadequate dental hygiene, mouth breathing, recurring tonsillitis, allergic rhinitis, laryngopharyngeal reflux, and exposure to smoke, chemicals, and other environmental pollutants. Allergic reactions to pollen, mold, and pet dander, chronic cough, excessive voice usage,...
Etiology
It often arises from persistent viral or bacterial infections affecting sinuses and tonsils.
Additional contributing factors include inadequate dental hygiene, mouth breathing, recurring tonsillitis, allergic rhinitis, laryngopharyngeal reflux, and exposure to smoke, chemicals, and other environmental pollutants. Allergic reactions to pollen, mold, and pet dander, chronic cough, excessive voice usage,...
989
01:23Cystic Fibrosis: Pathogenesis
182
Cystic fibrosis (CF), an autosomal recessive disorder, significantly affects the function of exocrine glands. This genetically inherited disease is characterized by the production of thick and sticky mucus, which can severely affect various organs and systems in the body.
CF is primarily caused by a genetic mutation in a chromosome 7 gene coding for the cystic fibrosis transmembrane conductance regulator (CFTR) protein. The most common gene mutation leading to CF is the ΔF508 mutation,...
CF is primarily caused by a genetic mutation in a chromosome 7 gene coding for the cystic fibrosis transmembrane conductance regulator (CFTR) protein. The most common gene mutation leading to CF is the ΔF508 mutation,...
182
01:30Tonsillitis I: Introduction
201
Tonsillitis is inflammation of the tonsils, which are two lymphoid tissue masses at the back of the throat. This condition can cause discomfort and irritation in the throat.
Etiology
Three primary contributing factors have been identified.
Etiology
Three primary contributing factors have been identified.
201
01:24Cystic Fibrosis: Management
139
Cystic fibrosis (CF) is an autosomal recessive disorder that predominantly affects individuals of Northern European descent, occurring at a rate of 1 in 3500. It is caused by a genetic mutation in a gene on chromosome 7, most commonly the ΔF508 mutation, that codes for the cystic fibrosis transmembrane conductance regulator (CFTR) protein. This results in thicker mucus secretions and obstruction pathologies in multiple organs, including the lungs and sinuses.
Sinus disease and chronic...
Sinus disease and chronic...
139