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Mesenchymal Stem Cells

Mesenchymal Stem Cells

Mesenchymal stem cells (MSCs) are adult stem cells that can differentiate into most connective tissue cell types, except for hematopoietic cells, depending upon the source of MSCs. For example, bone-marrow-derived MSCs (BM-MSCs) can differentiate into osteocytes, hepatocytes, and pancreatic and neuronal cells. MSCs can be isolated from various sources such as bone marrow, placenta, adipose tissue, teeth, and Wharton’s jelly, a gelatinous substance in the umbilical cord. The ease of their...

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Delayed Intramyocardial Delivery of Stem Cells after Ischemia Reperfusion Injury in a Murine Model

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Mesenchymal Stem Cell Therapy for Acute Myocardial Infarction: Protocol for a Systematic Review and Meta-Analysis.

Michael Vincent DiCaro¹, Brianna Yee¹, KaChon Lei¹

¹Division of Cardiovascular Medicine, Department of Internal Medicine, Kirk Kerkorian School of Medicine at UNLV, Las Vegas, NV, United States.

JMIR Research Protocols

|February 6, 2025

Summary

Mesenchymal stem cell (MSC) therapy shows potential for cardiac regeneration after myocardial infarction (MI). This systematic review synthesizes evidence on MSCs’ efficacy in improving heart function and reducing adverse events post-MI.

Keywords:

acute myocardial infarction cardiac efficacy medical therapy mesenchymal stem cells mesenchymal stromal cells meta-analysis myocardial outcomes progenitor cells protocol stem cell systematic review therapy

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Area of Science:

Cardiology
Regenerative Medicine
Stem Cell Therapy

Background:

Current treatments for acute myocardial infarction (MI) do not replace lost cells, leading to scar tissue formation.
Mesenchymal stem cells (MSCs) possess anti-inflammatory and immune-modulating properties that may aid cardiac regeneration.
This study protocol outlines a systematic review and meta-analysis to evaluate MSC therapy for acute MI.

Purpose of the Study:

To aggregate and synthesize clinical data on the effects of MSC therapy for acute MI.
To provide evidence for clinicians and researchers on using MSC therapy as an adjunct treatment.
To assess MSC therapy's role in improving functional cardiac outcomes and reducing adverse events.

Main Methods:

Systematic review and meta-analysis registered with PROSPERO.
Comprehensive search of Embase, PubMed, and Cochrane databases up to June 2023.
Screening of English-language human studies on adult patients receiving MSC therapy for acute MI, adhering to PRISMA guidelines.

Main Results:

Literature search and screening initiated in June 2023.
Data extraction and analysis are scheduled for completion by October 2024.
Synthesis and reporting of findings are expected by the end of November 2024.

Conclusions:

This systematic review will summarize current evidence on MSC therapy for acute MI.
The study aims to determine the efficacy of MSC therapy in enhancing cardiac function and structure.
Findings may guide the clinical application of MSCs to reduce adverse cardiac events post-MI.