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Protein binding of aluminium in normal subjects and in patients with chronic renal failure
Proceedings of the European Dialysis and Transplant Association - European Renal Association. European Dialysis and Transplant Association - European Renal Association. Congress
|January 1, 1985
Abstract:
Ultrafiltration of serum through YM10 membranes showed that 46 per cent of the aluminium in normal subjects and 33 per cent of the aluminium in patients with chronic renal failure is ultrafiltrable, suggesting that the majority of the aluminium is bound to some serum component(s) having molecular weight greater than 10,000 daltons. After desferrioxamine infusion, both the ultrafiltrable and protein-bound aluminium increases significantly, probably due to mobilisation of aluminium from body tissues. Gel filtration on Sephacryl S-300 and affinity chromatography have shown that transferrin is the major aluminium binding protein.