Related Experiment Video
Updated: May 29, 2025
Development of Obliterative Bronchiolitis in a Murine Model of Orthotopic Lung Transplantation
Published on: July 10, 2012
Adenovirus Infections and Disease in Solid Organ Transplant Recipients: Incidence and Outcomes
Katrine Riishøj Grarup1, Søren Schwartz Sørensen2,3, Michael Perch3,4
1Centre of Excellence for Health, Immunity and Infections, Copenhagen University Hospital, Rigshospitalet, Denmark.
Background:
We aimed to examine the epidemiology and outcomes of AdV disease in SOTr and assess the utility of AdV surveillance in SOTr <13 years.
Methods:
SOTr transplanted at Rigshospitalet, 2010-2021, were included. The center had a screening program for SOTr <13 years with monthly plasma AdV tests the first 6 months following transplantation.
Results:
We included 2009 SOTr (of whom 82 were aged <13 years), and 1330 blood samples from 382 SOTr were analyzed for AdV, of which 10 (0.8%) from 6 SOTr <13 years tested positive. Five out of six were tested as part of the screening program. Three remained asymptomatic, while three had symptoms attributable to co-infections. One adult lung transplant recipient with AdV in BAL had acute exacerbation of chronic graft rejection.
Conclusions:
We found a low incidence of AdV disease. SOTr diagnosed with AdV viremia as part of screening remained asymptomatic or had symptoms attributable to co-infections. Our findings do not support routine surveillance for AdV in SOTr.
