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Updated: May 29, 2025
Induction of Drug-Induced, Autoimmune Hepatitis in BALB/c Mice for the Study of Its Pathogenic Mechanisms
Published on: May 29, 2020
Drug-induced Autoimmune-like Hepatitis With Pathological Features of Giant Cell Hepatitis
Jie Yao1,2, Yongqin Yan3, Mei Ruan4
1Department of Hepatobiliary Disease, Fuzhou General Clinical Medical College of Fujian Medical University, The 900th Hospital of Joint Logistics Support Force, No. 156 West Second Ring North Road, Gulou District, Fuzhou, Fujian, 350025, China.
Background And Methods:
The differentiation between drug-induced autoimmune-like hepatitis (DI-ALH) and autoimmune hepatitis (AIH) can be confusing and challenging. We present a case of DI-ALH characterized by positive autoantibodies, elevated immunoglobulin G (IgG) levels and histology characteristics of giant cell hepatitis.
Results:
A liver biopsy was performed for etiology clarification, DI-ALH was diagnosed. Following treatment with corticosteroids and azathioprine, the patient's liver function remained normal without recurrence.
Conclusions:
Distinguishing DI-ALH from AIH based on the possibility of discontinuing immunosuppression and the histological features. Clinicians need to investigate patient's medical history, serological tests, and pathological changes to establish a correct diagnosis.
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