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Pharmacological Treatment of Presbyopia Using Pilocarpine 1.25% Eye Drops
Seyed Abolghasem Mousavi1, Zhale Rajavi1,2,3, Hamideh Sabbaghi3,4
1Negah Aref Ophthalmic Research Center, Shahid Beheshti University of Medical Sciences, Tehran, Iran.
Journal of Ophthalmic & Vision Research
|February 7, 2025
Summary
A new pilocarpine eye drop analogue (IR-Pilo) demonstrated comparable efficacy and safety to Vuity for improving near vision in presbyopia patients. Both treatments were effective and well-tolerated, with IR-Pilo showing a slight preference in near vision improvement.
Area of Science:
- Ophthalmology
- Optometry
- Pharmacology
Background:
- Presbyopia, a common age-related condition, affects near vision due to decreased accommodative amplitude.
- Pilocarpine hydrochloride is a miotic agent used to treat presbyopia by inducing miosis and increasing depth of focus.
Purpose of the Study:
- To compare the efficacy and safety of a pilocarpine eye drop 1.25% analogue (IR-Pilo) against its brand-name counterpart (Vuity).
- To evaluate the impact of these pilocarpine formulations on visual acuity, accommodation, pupil size, and intraocular pressure in presbyopic patients.
Main Methods:
- A non-randomized comparative study involving 75 patients aged 40-60 with presbyopia.
- Patients received either IR-Pilo or Vuity in one eye, with the contralateral eye serving as a control.
- Measurements included refractive error, distance best-corrected visual acuity (BCVA), near vision, accommodation amplitude, pupil size, and intraocular pressure (IOP) pre- and post-instillation.
Main Results:
- Both IR-Pilo and Vuity significantly improved near vision (P < 0.001), with a preference for IR-Pilo.
- Both formulations increased accommodation amplitude and caused pupil constriction, with IR-Pilo showing a greater effect.
- No significant changes in distance BCVA or intraocular pressure were observed; a minor myopic shift occurred with Vuity.
Conclusions:
- IR-Pilo and Vuity eye drops are comparable in effectiveness and safety for managing presbyopia.
- Both treatments provide stable distance vision and enhance near vision without significant adverse effects.
- IR-Pilo may offer a slight advantage in improving near vision and accommodative amplitude compared to Vuity.
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