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Related Experiment Video

Updated: Jul 10, 2026

Meal Duration as a Measure of Orofacial Nociceptive Responses in Rodents
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Perspective: Advancing the science regarding temporomandibular disorders.

Richard Ohrbach1, Alexandre F DaSilva2, Mildred C Embree3

  • 1Department of Oral Diagnostic Sciences, University at Buffalo School of Dental Medicine, Buffalo, NY, United States.

Frontiers in Dental Medicine
|February 7, 2025
PubMed
Summary

This Special Issue highlights systems biology for understanding Temporomandibular Disorders (TMDs). Integrating lab research and clinical observation is crucial for better TMD patient care and advancing scientific understanding.

Keywords:
precision medicineresearch methodsscience transfertemporomandibular disorderstemporomandibular joint

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Area of Science:

  • Multidisciplinary research
  • Systems biology
  • Musculoskeletal conditions

Background:

  • Temporomandibular Disorders (TMDs) are complex musculoskeletal conditions.
  • The National Academies of Sciences, Engineering, and Medicine (NASEM) called for improved TMD research.
  • Existing research and clinical practice require better integration.

Purpose of the Study:

  • To emphasize the critical role of systems biology in advancing Temporomandibular Disorders (TMD) research.
  • To address the NASEM recommendations for broadening TMD research scope.
  • To improve the integration of basic and clinical sciences for TMDs.

Main Methods:

  • Analysis of three publications within a Special Issue.
  • Focus on laboratory research and clinical observation domains.
  • Synthesis of findings related to systems biology approaches for TMDs.

Main Results:

  • Systems biology is essential for understanding TMDs.
  • Integration of laboratory and clinical data is vital.
  • Three publications underscore the need for broader, integrated TMD research.

Conclusions:

  • Adopting a systems biology approach will enhance understanding of complex TMDs.
  • Improved integration of basic and clinical science is necessary for better patient care.
  • Clinicians should utilize existing evidence while advocating for more research to improve patient outcomes.