Related Experiment Video

Updated: Jul 1, 2026

Intranasal Delivery of Therapeutic Stem Cells to Glioblastoma in a Mouse Model
09:57

Intranasal Delivery of Therapeutic Stem Cells to Glioblastoma in a Mouse Model

Published on: June 4, 2017

12.1K

Bringing intranasal drug delivery for malignancies in the brain to market

Thomas C Chen1,2,3, Clovis O da Fonseca4, Axel H Schönthal5

  • 1Department of Neurological Surgery, Keck School of Medicine, University of Southern California (USC), Los Angeles, CA, USA.

Expert Opinion on Drug Delivery
|February 7, 2025
PubMed
Abstract

No abstract available in PubMed .

Keywords:
Blood–brain barrierNEO100brain cancergliomameningiomanose-to-brain pathwayperillyl alcoholtemozolomide

More Related Videos

Novel Methods for Intranasal Administration Under Inhalation Anesthesia to Evaluate Nose-to-Brain Drug Delivery
05:44

Novel Methods for Intranasal Administration Under Inhalation Anesthesia to Evaluate Nose-to-Brain Drug Delivery

Published on: November 14, 2018

20.0K
A Positioning Device for the Placement of Mice During Intranasal siRNA Delivery to the Central Nervous System
05:28

A Positioning Device for the Placement of Mice During Intranasal siRNA Delivery to the Central Nervous System

Published on: August 15, 2019

23.1K

Related Experiment Videos

Last Updated: Jul 1, 2026

Intranasal Delivery of Therapeutic Stem Cells to Glioblastoma in a Mouse Model
09:57

Intranasal Delivery of Therapeutic Stem Cells to Glioblastoma in a Mouse Model

Published on: June 4, 2017

12.1K
Novel Methods for Intranasal Administration Under Inhalation Anesthesia to Evaluate Nose-to-Brain Drug Delivery
05:44

Novel Methods for Intranasal Administration Under Inhalation Anesthesia to Evaluate Nose-to-Brain Drug Delivery

Published on: November 14, 2018

20.0K
A Positioning Device for the Placement of Mice During Intranasal siRNA Delivery to the Central Nervous System
05:28

A Positioning Device for the Placement of Mice During Intranasal siRNA Delivery to the Central Nervous System

Published on: August 15, 2019

23.1K

Related Concept Videos

Drug Delivery: Parenteral Route01:29

Drug Delivery: Parenteral Route

The parenteral route is a critical method of drug administration. It delivers compounds directly into the systemic circulation and bypasses the gastrointestinal tract. This approach is particularly advantageous for drugs that exhibit poor absorption or instability when administered orally.
There are three primary parenteral routes: intravenous (IV), intramuscular (IM), and subcutaneous (SC). The IV route introduces the drug directly into the bloodstream, ensuring immediate action. The IM route...
Drug Delivery: Miscellaneous Routes01:22

Drug Delivery: Miscellaneous Routes

Drug delivery methods like oral inhalation, nasal sprays, transdermal patches, eye drops, intravitreal injection,  and rectal administration provide localized effects with reduced toxicity.
Oral inhalation and nasal sprays swiftly transfer drugs across the respiratory epithelium's mucosal layer. Inhaled glucocorticoids and bronchodilators directly target lung conditions such as asthma, while fluticasone nasal spray mitigates allergic rhinitis.
Transdermal patches transport drugs through the...

Articles linked to this work by shared authors, journal, and citation graph.

Protocol for a pilot-randomized trial in newly diagnosed glioblastoma: standard care with or without daily intranasal perillyl alcohol.

Future oncology (London, England)·2026

Safety and functional evaluation of a synthetic lamina cover that replaces lost autologous spinal bone after laminectomy, in a sheep and human study.

North American Spine Society journal·2025

Potent Therapeutic Activity of NEO212 in Preclinical Models of Human and Canine Leukaemia and Lymphoma.

Veterinary and comparative oncology·2025

Patient with recurrent grade 4 astrocytoma responding favorably to intranasal delivery of NEO100, highly pure perillyl alcohol: illustrative case.

Journal of neurosurgery. Case lessons·2025

Characterization of cerebrospinal fluid markers as indicators of spinal cord ischemia following an endovascular aortic aneurysm repair procedure.

Journal of neurosurgery·2024

Application and Safety of Externally Controlled Metronomic Drug Delivery to the Brain by an Implantable Smart Pump in a Sheep Model.

Neurosurgery·2024

Strategies for endoplasmic reticulum-targeted delivery systems: current design principles and trends.

Expert opinion on drug delivery·2026

Recent advancements and translational potentials of MOF-based precision strategies for breast cancer therapy.

Expert opinion on drug delivery·2026

Preclinical and clinical evaluation of an ocular nanoemulsion for the treatment of dry eye disease.

Expert opinion on drug delivery·2026

Bridging the gap: using organ-on-a-chip technology to evaluate nanoparticle enzyme replacement therapy for lysosomal storage diseases.

Expert opinion on drug delivery·2026

Cubosome-based skin delivery: from topical to transdermal applications.

Expert opinion on drug delivery·2026

Quercetin for diabetic retinopathy: from molecular targets to targeted delivery strategies.

Expert opinion on drug delivery·2026

Research progress in synergistic multimechanism of nanomaterial-mediated neuroinflammatory therapy (Review).

Molecular medicine reports·2026

Silver sodium nitroprusside nano-aggregates for ultrasound-activated immunomodulatory therapy of MRSA pneumonia.

Biomedical materials (Bristol, England)·2026

Neuro-psycho MMSig: multimodal mechanism enrichment platform for neuropsychiatric disorders.

Frontiers in bioinformatics·2026

Portable Ultra-Low-Field MRI in Neurologic Diseases: Current Status and Potential in Clinical Practice, Research, and Trials.

Neurology·2026

Venetoclax-based therapy versus hypomethylating agents alone in unfit patients with newly diagnosed acute myeloid leukemia: a real-world study from the PETHEMA registry.

Leukemia·2026

Ultrasound-Enhanced Transport of Nanoparticles Through Extracellular Matrix-Acoustic Streaming and Diffusion.

Ultrasound in medicine & biology·2026
See all related articles
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies
Jove
Visualize
Contact Us