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Updated: May 5, 2026
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Rat Model of the Associating Liver Partition and Portal Vein Ligation for Staged Hepatectomy ALPPS Procedure
Published on: August 14, 2017
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[Laparoscopic ALPPS procedure: a series of cases]
V K Lyadov1,2,3, A N Moskalenko1, M M Magomedov1
1Yudin Moscow City Clinical Hospital, Moscow, Russia.
Khirurgiia
|February 7, 2025
Summary
Laparoscopic associated liver partition and portal vein ligation for staged hepatectomy (ALPPS) is feasible for liver tumors, showing good short-term and long-term outcomes. This complex procedure requires specialized high-volume centers for optimal results.
Area of Science:
- Hepatobiliary surgery
- Minimally invasive surgical techniques
- Oncology
Context:
- Liver resection combined with chemotherapy is standard for malignant liver tumors.
- Associated liver partition and portal vein ligation for staged hepatectomy (ALPPS) enhances resectability.
- Laparoscopic approaches are increasingly explored for complex liver procedures.
Purpose:
- To assess the feasibility and outcomes of laparoscopic ALPPS.
- To evaluate short-term and long-term results of this minimally invasive technique.
- To determine the safety and efficacy of laparoscopic ALPPS in liver cancer treatment.
Summary:
- Six laparoscopic ALPPS procedures were performed for liver metastases and cholangiocarcinoma in patients with insufficient liver remnant volume.
- The first stage was completed laparoscopically without complications; the second stage had complications including biliary fistula and hydrothorax in some patients.
- A median follow-up of 25 months showed R0 resection in 4 patients, with 3 deaths due to cancer progression or unrelated causes.
Impact:
- Laparoscopic ALPPS can be successfully performed, offering good oncological outcomes.
- This technique requires experienced surgical teams and high-volume centers for safe execution.
- Laparoscopic ALPPS represents a viable minimally invasive option for selected liver cancer patients.
