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Treatment of Type 2 Diabetes in Patients with Obesity: A Review
Heidi Guzman1, Leen Z Hasan1, Tirissa J Reid1
1Division of Endocrinology, Diabetes and Metabolism, Department of Medicine, Columbia University College of Physicians and Surgeons, Columbia University Irving Medical Center, New York, NY, USA.
Abstract:
Type 2 diabetes and obesity have some overlapping pathophysiology. This has allowed for the creation of therapies which are highly effective in treating both conditions. Weekly subcutaneous incretin agonists are preferred agents as they provide significant improvement in glycemic parameters, weight, and other comorbidities, like heart failure and reduce major adverse cardiovascular event. Bariatric surgery continues to show the most durable benefits for patients with both type 2 diabetes mellitus and obesity and should be considered in patients who are unable to meet goals with pharmacotherapy and lifestyle.
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