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Aging With Cystic Fibrosis: Endocrine and Metabolic Considerations
Katie Kaput1, Samantha Steinmetz-Wood2, Melissa S Putman3
1Department of Medicine, University of Utah, Salt Lake City, Utah.
Summary
Cystic fibrosis (CF) is now a chronic adult disease due to improved survival. This review highlights age-related endocrine and metabolic issues in adults with CF, stressing early screening and tailored care.
Area of Science:
- Endocrinology
- Metabolic disorders
- Chronic disease management
Background:
- Cystic fibrosis (CF) is increasingly a chronic adult condition, not just a pediatric disease.
- Prolonged survival with CFTR modulator therapy leads to age-related complications.
- Endocrine and metabolic issues like diabetes, bone disease, and obesity are common in aging CF patients.
Purpose of the Study:
- To review current evidence on endocrine and metabolic complications in adults with CF.
- To emphasize the need for early screening and multidisciplinary management.
- To highlight the evolving health needs of the aging CF population.
Main Methods:
- Literature review of current evidence on endocrine and metabolic complications in CF.
- Focus on age-related issues and impact of CFTR modulator therapy.
- Analysis of management strategies and quality-of-life considerations.
Main Results:
- Adults with CF face significant age-related endocrine and metabolic challenges.
- Diabetes, bone disease, menopause, and obesity are key concerns.
- Current clinical guidelines may not adequately address the needs of the aging CF population.
Conclusions:
- Early screening and multidisciplinary care are crucial for managing endocrine and metabolic complications in adults with CF.
- CF-specific population studies are needed to adapt clinical practice guidelines.
- Addressing these evolving health needs is vital for improving quality of life in the aging CF population.
Keywords:
agingcardiovascular diseasecystic fibrosiscystic fibrosis-related bone diseasecystic fibrosis–related diabetesmenopauseMore Related Videos
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