Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

The JAK-STAT Signaling Pathway01:20

The JAK-STAT Signaling Pathway

8.6K
Several cytokine receptors have tightly bound Janus kinase or JAK proteins attached at their cytosolic tail. Small signaling molecules such as cytokines, growth hormones, or prolactins bind to the cytokine receptors and initiate their dimerization. The dimerization brings the cytosolic JAKs together that trans-phosphorylate and activates each other. The activated JAKs now phosphorylate cytosolic tails of the cytokine receptors, which serve as binding sites for adaptor proteins such as  SH2...
8.6K
Transcription Factors02:16

Transcription Factors

75.6K
Tissue-specific transcription factors contribute to diverse cellular functions in mammals. For example, the gene for beta globin, a major component of hemoglobin, is present in all cells of the body. However, it is only expressed in red blood cells because the transcription factors that can bind to the promoter sequences of the beta globin gene are only expressed in these cells. Tissue-specific transcription factors also ensure that mutations in these factors may impair only the function of...
75.6K
Master Transcription Regulators02:23

Master Transcription Regulators

6.9K
Master transcription regulators are regulatory proteins that are predominantly responsible for regulating the expression of multiple genes. Often these genes work in concert to drive a  complex process. Activation of a master transcription regulator can lead to a cascade of transcriptional activation necessary for that outcome. These regulators can directly bind to the regulatory sequences of the various genes involved, or they can indirectly regulate transcription by binding to regulatory...
6.9K
Aging01:26

Aging

35
Aging is a complex biological phenomenon influenced by various processes that affect cellular and systemic functions. Several prominent theories attempt to explain its mechanisms, highlighting cellular limitations, oxidative damage, and hormonal changes as central factors in aging.
Cellular Clock Theory
The cellular clock theory posits that the human lifespan is closely tied to the finite capacity of cells to divide, a phenomenon governed by telomeres, which are protective caps at the ends of...
35
PI3K/mTOR/AKT Signaling Pathway01:22

PI3K/mTOR/AKT Signaling Pathway

3.4K
The mammalian target of rapamycin  (mTOR) is a serine/threonine kinase that regulates growth, proliferation, and cell survival in response to hormones, growth factors, or nutrient availability. This kinase exists in two structurally and functionally distinct forms: mTOR complex 1  (mTORC1) and mTOR complex 2  (mTORC2). The first form (mTORC1) is composed of a rapamycin-sensitive Raptor and proline-rich Akt substrate, PRAS40. In contrast,  mTORC2 consists of a...
3.4K
General Transcription Factors01:30

General Transcription Factors

5.1K
Tissue-specific transcription factors contribute to diverse cellular functions in mammals. For example, the gene for beta globin, a major component of hemoglobin, is present in all cells of the body. However, it is only expressed in red blood cells because the transcription factors that can bind to the promoter sequences of the beta globin gene are only expressed in these cells. Tissue-specific transcription factors also ensure that mutations in these factors may impair only the function of...
5.1K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Piezo1 as a novel therapeutic target of salvianolic acid B for metabolic dysfunction-associated steatotic liver disease.

Phytomedicine : international journal of phytotherapy and phytopharmacology·2026
Same author

Single-cell Transcriptomic Atlas of Ovarian Endometriosis Patient's Follicular Fluid: Unraveling Novel Insights into Abnormal Follicular Development.

Reproduction (Cambridge, England)·2026
Same author

SPINDOC functions as a mitotic molecular counter to coordinate spatiotemporal CENP-A assembly.

Cell reports·2026
Same author

Mental health in early pregnancy: Interplay of objectively measured lifestyles, gut microbiota, and metabolomics.

iScience·2026
Same author

Online matrix elimination and high-sensitivity detection of maleic hydrazide in complex vegetable matrices using 2D-IC-IPAD.

Food chemistry·2026
Same author

An integrated single-nucleus ribonucleic acid sequencing and spatial transcriptomic atlas reveals stage-specific neuronal and glial trajectories in a mouse model of amyotrophic lateral sclerosis.

Neural regeneration research·2026

Related Experiment Video

Updated: May 29, 2025

Merging Absolute and Relative Quantitative PCR Data to Quantify STAT3 Splice Variant Transcripts
11:19

Merging Absolute and Relative Quantitative PCR Data to Quantify STAT3 Splice Variant Transcripts

Published on: October 9, 2016

14.9K

The transcription factor STAT3 and aging: an intermediate medium.

Min Shi1, Honyu Li1, Runyu Liang1

  • 1Heilongjiang University of Chinese Medicine, Harbin, 150040, Heilongjiang, China.

Biogerontology
|February 7, 2025
PubMed
Summary

Signal transducer and activator of transcription 3 (STAT3) plays a key role in aging and related diseases. Targeting STAT3 may offer future therapeutic strategies for delaying aging and treating age-related conditions.

Keywords:
Aging mechanismAging-related diseasesSTAT3

More Related Videos

Describing a Transcription Factor Dependent Regulation of the MicroRNA Transcriptome
07:23

Describing a Transcription Factor Dependent Regulation of the MicroRNA Transcriptome

Published on: June 15, 2016

8.4K
Skeletal Phenotype Analysis of a Conditional Stat3 Deletion Mouse Model
08:42

Skeletal Phenotype Analysis of a Conditional Stat3 Deletion Mouse Model

Published on: July 3, 2020

4.3K

Related Experiment Videos

Last Updated: May 29, 2025

Merging Absolute and Relative Quantitative PCR Data to Quantify STAT3 Splice Variant Transcripts
11:19

Merging Absolute and Relative Quantitative PCR Data to Quantify STAT3 Splice Variant Transcripts

Published on: October 9, 2016

14.9K
Describing a Transcription Factor Dependent Regulation of the MicroRNA Transcriptome
07:23

Describing a Transcription Factor Dependent Regulation of the MicroRNA Transcriptome

Published on: June 15, 2016

8.4K
Skeletal Phenotype Analysis of a Conditional Stat3 Deletion Mouse Model
08:42

Skeletal Phenotype Analysis of a Conditional Stat3 Deletion Mouse Model

Published on: July 3, 2020

4.3K

Area of Science:

  • Gerontology and cellular biology
  • Molecular mechanisms of aging
  • Inflammation and disease pathogenesis

Background:

  • Aging is characterized by declining cellular function and increased susceptibility to age-related diseases.
  • Signal transducer and activator of transcription 3 (STAT3) is a critical regulator involved in metabolism, development, senescence, and apoptosis.
  • Dysregulation of STAT3 contributes to aging processes and associated pathologies.

Purpose of the Study:

  • To review the multifaceted role of STAT3 signaling in the pathogenesis of aging.
  • To elucidate STAT3's involvement in key aging hallmarks such as mitochondrial dysfunction, cellular senescence, and autophagy.
  • To highlight the therapeutic potential of targeting STAT3 for age-related diseases.

Main Methods:

  • Literature review and synthesis of existing research on STAT3 and aging.
  • Analysis of STAT3's regulatory functions in cellular processes relevant to aging.
  • Examination of the link between STAT3 activation, inflammation, and senescence.

Main Results:

  • STAT3 activation is modulated by growth factors and cytokines during aging.
  • STAT3 influences inflammatory pathways, mitochondrial function, cellular senescence, and autophagy.
  • STAT3 signaling is integral to the development of various aging-related diseases.

Conclusions:

  • STAT3 is a central regulator influencing multiple facets of the aging process.
  • Targeting STAT3 pathways presents a promising avenue for therapeutic interventions in aging and senescence-related diseases.
  • Future drug development and clinical applications focused on STAT3 hold significant potential for mitigating aging and treating age-related conditions.