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Updated: May 5, 2026
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Amide Coupling Reaction for the Synthesis of Bispyridine-based Ligands and Their Complexation to Platinum as Dinuclear Anticancer Agents
Published on: May 28, 2014
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Drug delivery for platinum therapeutics
Hui Liu1, Jiahui Zou1, Xiaotong Li1
1School of Pharmacy, China Pharmaceutical University, Nanjing 2111198, PR China.
Summary
Platinum drugs are vital cancer treatments but have side effects. This review explores advanced platinum drug delivery systems to enhance efficacy and reduce toxicity for better cancer therapy.
Area of Science:
- Oncology
- Nanomedicine
- Drug Delivery Systems
Background:
- Platinum-based chemotherapy agents, including cisplatin (CDDP), oxaliplatin, and carboplatin, are mainstays in treating numerous solid tumors.
- Despite their efficacy, clinical application is limited by significant side effects such as nephrotoxicity, ototoxicity, and the development of drug resistance.
- There is a critical need for innovative strategies to improve platinum drug delivery, aiming for enhanced tumor accumulation and reduced systemic toxicity.
Purpose of the Study:
- To review the current progress, mechanisms, clinical applications, and limitations of platinum-based anticancer drugs.
- To comprehensively summarize advanced platinum drug delivery systems, including drug carriers and responsive strategies.
- To highlight platinum delivery formulations currently in clinical trials and provide future perspectives.
Main Methods:
- Literature review of platinum-based chemotherapy, drug delivery systems, and nanomedicine.
- Analysis of existing research on drug carriers and responsive strategies for platinum drugs.
- Examination of clinical trial data for platinum delivery formulations.
Main Results:
- Platinum drugs exhibit potent anticancer properties but face challenges with toxicity and resistance.
- Various drug carriers and responsive strategies are being developed to improve platinum drug targeting and controlled release.
- Several platinum delivery formulations are progressing through clinical trials, showing promise for improved therapeutic outcomes.
Conclusions:
- Advanced delivery systems are crucial for overcoming the limitations of conventional platinum chemotherapy.
- Targeted delivery and controlled release of platinum drugs can enhance antitumor efficacy while mitigating side effects.
- Continued research and clinical evaluation of novel platinum delivery strategies are essential for advancing cancer treatment.
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