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Cellular Proliferation Imaging With 18 F-FMAU PET/CT as Adjunct to mpMRI in Image-Guided Biopsy of Suspected Prostate

Hossein Jadvar1, Kai Chen1, Passant Mohamed1

  • 1Division of Nuclear Medicine and Molecular Imaging Center, Department of Radiology.

Clinical Nuclear Medicine
|February 10, 2025
PubMed
Abstract

Insights

18F-FMAU PET/CT shows promise as an adjunct to multiparametric MRI (mpMRI) for guiding prostate biopsies. This cellular proliferation imaging helps improve cancer detection in men with suspected prostate cancer.

Area of Science:

  • Nuclear medicine
  • Radiopharmaceuticals
  • Prostate cancer diagnostics

Background:

  • Multiparametric MRI (mpMRI) is standard for prostate cancer detection.
  • Accurate localization for biopsy remains challenging.
  • Novel imaging biomarkers are needed to enhance diagnostic utility.

Purpose of the Study:

  • To evaluate the diagnostic performance of 2'-deoxyl-2'-[18F]fluoro-5-methyl-1-beta-D-arabinofuranosyluracil (18F-FMAU) PET/CT.
  • To assess its utility as an adjunct to mpMRI for image-guided prostate biopsy.
  • To improve the localization of cancerous sites in men with suspected prostate cancer.

Main Methods:

  • Seventeen men with suspected prostate cancer underwent both mpMRI and 18F-FMAU PET/CT.
  • Twenty-two image-guided biopsies were performed.
  • Histological examination of tissue samples determined cancer presence and grade (ISUP 1 and 2).

Main Results:

  • mpMRI sensitivity for ISUP 1 and ISUP 2 tumors was 16.7% and 100%, respectively.
  • 18F-FMAU PET/CT sensitivity for ISUP 1 and ISUP 2 tumors was 50% and 60%, respectively.
  • The combination of imaging modalities warrants further investigation.

Conclusions:

  • 18F-FMAU PET/CT demonstrates potential as an adjunctive tool in prostate cancer diagnostics.
  • It may improve the accuracy of image-guided biopsies when used with mpMRI.
  • Further research is needed to fully establish its role in clinical practice.
Keywords:
FMAUMRIPETbiopsycancerprostate

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