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Updated: Jun 23, 2026

High-throughput Analysis of Mammalian Olfactory Receptors: Measurement of Receptor Activation via Luciferase Activity
Published on: June 2, 2014
Development of MhOR1 as a chemogenetic tool for odorant-mediated regulation of insulin release
Hanbing Li1, Gaojun Chen1, Xiayan Lou1
1Institute of Pharmacology, College of Pharmaceutical Science, Zhejiang University of Technology, Hangzhou, 310014, China.
Abstract:
Our study presents MhOR1, an odorant-responsive chemogenetic tool that facilitates calcium influx upon odorant activation. We optimized its membrane expression and demonstrated its ability to regulate insulin release in pancreatic β cells. Our results suggest that MhOR1 holds potential for gene regulation and therapeutic applications through odorant-triggered cellular activities.
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