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Related Experiment Video

Updated: Jul 12, 2026

Effect of Hyaluronic Acid 35 kDa on an In Vitro Model of Preterm Small Intestinal Injury and Healing Using Enteroid-Derived Monolayers
09:36

Effect of Hyaluronic Acid 35 kDa on an In Vitro Model of Preterm Small Intestinal Injury and Healing Using Enteroid-Derived Monolayers

Published on: July 28, 2022

Predictors of Neurodevelopmental Impairment after Intestinal Resection for Necrotizing Enterocolitis: A Multicenter

Utsav M Patwardhan1, Alex Gonzalez1, Insiyah Campwala2

  • 1Division of Pediatric Surgery, Rady Children's Hospital, San Diego, CA.

Annals of Surgery
|February 10, 2025
PubMed
Summary

The number of metabolic derangement indicators before surgery for necrotizing enterocolitis (NEC) predicts neurodevelopmental impairment (NDI) risk. Early identification of these indicators may improve infant outcomes.

Keywords:
intestinal resectionnecrotizing enterocolitisneonatalneurodevelopmental impairmentpredictors

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Related Experiment Videos

Last Updated: Jul 12, 2026

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Published on: July 28, 2022

Microfluidic Model of Necrotizing Enterocolitis Incorporating Human Neonatal Intestinal Enteroids and a Dysbiotic Microbiome
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Microfluidic Model of Necrotizing Enterocolitis Incorporating Human Neonatal Intestinal Enteroids and a Dysbiotic Microbiome

Published on: July 28, 2023

A Neonatal Mouse Model of Necrotizing Enterocolitis and Lamina Propria Isolation for Immune Cell Profiling
09:13

A Neonatal Mouse Model of Necrotizing Enterocolitis and Lamina Propria Isolation for Immune Cell Profiling

Published on: September 19, 2025

Area of Science:

  • Pediatric Surgery
  • Neonatal Medicine
  • Neurodevelopmental Pediatrics

Background:

  • Surgical necrotizing enterocolitis (NEC) carries a significant risk of neurodevelopmental impairment (NDI).
  • Identifying pre-resection risk factors is crucial for optimizing surgical timing and improving outcomes.

Purpose of the Study:

  • To evaluate pre-resection risk factors for NDI in infants with NEC.
  • To inform the optimal timing of intestinal resection in NEC management.

Main Methods:

  • Retrospective study of 365 NEC patients undergoing intestinal resection (2010-2019) across 11 US children's hospitals.
  • Assessed demographics, NEC diagnosis findings, and the presence/trajectory of metabolic derangement indicators as predictors of NDI at 16-26 months.

Main Results:

  • NDI occurred in 55% of assessed patients, more frequent in males, lower birth weight/gestational age/Apgar scores, and older age at diagnosis.
  • Increased pre-resection metabolic derangement indicators correlated with higher NDI risk (1.78 vs 1.15, P=0.002).
  • NDI risk escalated from 44% to 83% with 0-5 indicators detected (P=0.04), with progressive detection times.

Conclusions:

  • The number and timing of metabolic derangement indicators before resection are associated with NDI risk in surgical NEC.
  • Assessing these indicators may objectively define medical management failure and enhance neurodevelopmental outcomes in NEC.