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Impact of Fixed Orthodontic Appliances on Blood Count and High-Sensitivity C-Reactive Protein Levels
Jiwanasha Manish Agrawal1, Vidyesh Nadkerny2, Anurag Tiwari3
1Department of Orthodontics and Dentofacial Orthopaedics, Bharati Vidyapeeth (Deemed to be) University Pune, Dental College and Hospital, Sangli, Maharashtra, India.
Background:
Fixed orthodontic appliances are widely used in dental practice to correct malocclusions and improving oral health. However, their impact on systemic inflammation and hematological parameters remains under-explored.
Materials And Methods:
A cohort of 60 patients, aged 12 -30 years, undergoing fixed orthodontic treatment, were enrolled in the study. Blood samples were collected at baseline, 1 month, and 6 months post-appliance placement. Hematological parameters, including white blood cell (WBC) count, red blood cell (RBC) count, hemoglobin levels, and hs-CRP levels, were measured using standard laboratory techniques. A statistical analysis was performed to determine significant changes over time.
Results:
At 1-month post-appliance placement, a significant increase in WBC count (mean increase of 12%) and hs-CRP levels (mean increase of 18%) was observed compared to baseline (P < 0.05). RBC count and hemoglobin levels remained relatively unchanged. By 6 months, WBC count and hs-CRP levels showed a decreasing trend, approaching baseline values, though hs-CRP levels remained slightly elevated (mean increase of 5% from baseline, P > 0.05).
Conclusion:
The use of fixed orthodontic appliances induces a transient inflammatory response, as evidenced by elevated WBC count and hs-CRP levels within the first month of treatment.
