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A Doxorubicin-Induced Murine Model of Dilated Cardiomyopathy In Vivo

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Steroid Induced Dialated Cardiomyopathy.

Meenaxi Sharda¹, B G Gokul², Dheeraj Krishna³

¹Senior Professor; Department of General Medicine, Government Medical College, Kota, Rajasthan, India.

The Journal of the Association of Physicians of India

|February 10, 2025

Summary

This summary is machine-generated.

This case highlights a 37-year-old male with severe shortness of breath and generalized swelling, likely due to chronic alcohol and smoking-induced heart or kidney issues. Prompt diagnosis is crucial for managing these critical symptoms.

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Area of Science:

Cardiology
Nephrology
Internal Medicine

Background:

A 37-year-old male presented with a 15-day history of worsening shortness of breath, pedal edema, facial puffiness, abdominal distension, generalized swelling, and oliguria.
The patient reported a 3-year history of breathlessness attacks treated with inhalational therapy and oral steroids (Betnesol).
Significant risk factors include a 10-year history of chronic smoking and alcohol consumption.

Purpose of the Study:

To present a case of a young male with severe systemic symptoms suggestive of advanced cardiopulmonary or renal disease.
To emphasize the importance of considering lifestyle factors like chronic smoking and alcoholism in the differential diagnosis of unexplained edema and shortness of breath.

Main Methods:

Clinical case presentation.
Review of patient's reported medical history, including substance use and prior treatments.
Physical examination findings including generalized edema, abdominal distension, and oliguria.

Main Results:

The patient exhibited significant fluid overload symptoms (edema, ascites) and reduced urine output (oliguria).
Progressive dyspnea was the primary complaint, exacerbated by a history of steroid and inhalational therapy for breathlessness.
Chronic alcohol and smoking history are key etiological considerations.

Conclusions:

This case underscores the potential for severe cardiopulmonary or renal compromise in young individuals with a history of chronic smoking and alcoholism.
Further investigation is warranted to determine the underlying etiology of the patient's symptoms, likely related to substance abuse.
Early and comprehensive diagnostic workup is essential for appropriate management.