Inflammatory Choroidal Neovascularization in Pediatric Uveitis: A Case Series
Amandine Gauderon1, Chiara Eandi2, Aikaterini Koryllou3
1Jules-Gonin Eye Hospital, FAA, Uveitis Clinic, Department of Ophthalmology, University of Lausanne, Switzerland.
Klinische Monatsblatter Fur Augenheilkunde
|February 10, 2025
Summary
Anti-VEGF therapy is safe and effective for treating choroidal neovascularization (CNV) in children with uveitis. Minimal injections are needed, and treating the underlying inflammation is key for good outcomes.
Area of Science:
- Ophthalmology
- Pediatric Ophthalmology
- Inflammatory Eye Disease
Background:
- Choroidal neovascularization (CNV) in children is often secondary to ocular inflammation, such as uveitis.
- Understanding the clinical features, treatment, and outcomes of pediatric inflammatory CNV is crucial for effective management.
Purpose of the Study:
- To describe the clinical characteristics, therapeutic interventions, and outcomes of children diagnosed with inflammatory choroidal neovascularization (CNV).
Main Methods:
- A retrospective case series was conducted involving children diagnosed with macular CNV secondary to ocular inflammation.
- Data were collected from patients seen at a specialized eye hospital between 2000 and 2024.
Main Results:
- Four children with inflammatory CNV were identified, presenting with unilateral disease after uveitis onset.
- Treatments included oral steroids, adalimumab, antibiotics, and anti-VEGF injections, with generally good visual acuity outcomes.
- No CNV recurrence was observed, even with uveitis reactivation.
Conclusions:
- Anti-VEGF therapy demonstrates safety and efficacy in pediatric patients with inflammatory CNV, requiring minimal interventions.
- Effective management necessitates addressing the underlying cause of uveitis alongside CNV treatment.
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