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Exercise-mediated epigenetic modifications in cardiovascular diseases.

Xinyu Yang1,2,3,4, Yanqi Zhang1,2,3,4, Xingyi Wang1,2,3,4

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Epigenomics
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Regular exercise can modify cardiovascular disease risk through epigenetic changes. This study explores how exercise impacts DNA methylation, lactylation, and m6A RNA modifications for potential CVD prevention and management.

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Area of Science:

  • Cardiovascular Science
  • Epigenetics
  • Exercise Physiology

Background:

  • Cardiovascular diseases (CVDs) are a leading cause of death, with aging populations increasing the burden.
  • Exercise is known to reduce CVD risk, but the underlying epigenetic mechanisms are not fully understood.

Purpose of the Study:

  • To investigate exercise-induced epigenetic alterations and their effects on cardiovascular health.
  • To explore the specific epigenetic mechanisms, including DNA methylation, lactylation, and m6A RNA modifications, influenced by exercise.

Main Methods:

  • Review of current research on exercise and epigenetic modifications in the context of CVDs.
  • Analysis of cardiac implications of exercise-induced epigenetic changes at various intensities.
  • Examination of the molecular mechanisms of DNA methylation, lactylation, and m6A RNA modifications.

Main Results:

  • Exercise induces epigenetic modifications that impact cardiovascular health.
  • Specific mechanisms include changes in DNA methylation, lactylation, and N6-methyladenosine (m6A) RNA.
  • These exercise-mediated epigenetic changes show therapeutic potential for CVD prevention and management.

Conclusions:

  • Exercise-induced epigenetic modifications offer a promising avenue for CVD prevention and comorbidity management.
  • Further targeted research is needed due to the heterogeneity and tissue specificity of these effects.
  • Understanding these mechanisms can unlock new therapeutic strategies for cardiovascular diseases.